In the recent years promising results have been shown by use of Compression optical coherence elastography (C-OCE) as a new biopsy approach to morphological assessment/diagnostics human breast cancer using differences in elastic properties components cancerous tissues. this study, for first time, relationship was established between microstructural organization and biomechanical breast-cancer t...

BACKGROUND To investigate the expression and role of PBRM1 in breast cancer, and to evaluate the clinical and prognostic significance of PBRM1 protein in patients with breast cancer. METHODS The expression of PBRM1 was examined in breast cancer tissue and paired non-cancerous tissues by real-time PCR. Moreover, PBRM1 protein expression was evaluated by immunohistochemistry in 150 paraffin-emb...

Breast cancer is a serious potential health problem for all women and is the second leading cause of cancer deaths in the United States. The current screening procedures and imaging techniques, including x-ray mammography, clinical biopsy, ultrasound imaging, and magnetic resonance imaging, provide only 73% accuracy in detecting breast cancer. This gives the impetus to explore alternate techniq...

In this paper, we investigate the properties of the cell-graphs by using the spectral graph theory. The spectral analysis is performed on (i) the adjacency matrix of a cell-graph, and (ii) the normalized Laplacian of the cell-graph. We show that the spectra of the cell-graphs of cancerous tissues are unique and the features extracted from these spectra distinguish the cancerous (malignant gliom...

Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specim...

Lysosome associated membrane protein-1 (LAMP1) is a heavily glycosylated lysosomal membrane protein, which is able to protect the lysosomal membrane from intracellular proteolysis. LAMP1 has been implicated in cancer development and progression. However, LAMP1 expression in breast cancer (BC) and its relationship with the clinical parameters of BC has not yet been fully investigated. In the pre...

In this study, a novel animal model for the breast cancer treatment which contains hyperthermia is proposed. For main purpose low cost, interstitial, bioimplant antenna by short ended single slot design proposed to heat cancerous tissues. Both theoretical background of system and simulation measurement results are presented. An artificial tissue phantom has been created under laboratory conditi...

The enzyme telomerase catalyzes the de novo synthesis of telomere repeats, thereby maintaining telomere length, which is necessary for unlimited cellular proliferation. Telomerase reverse transcriptase (TERT), the catalytic domain of telomerase, is the rate-limiting factor for telomerase activity and is expressed in virtually all tumors. Thus, TERT has been proposed as a marker with diagnostic ...