AIM To report the long-term results of high-dose-rate (HDR) brachytherapy (BT) boost for breast cancer patients treated with conservative surgery and radiotherapy. MATERIALS AND METHODS Between 1995 and 2007, 100 early-stage breast cancer patients received an HDR BT boost after conservative surgery and whole breast irradiation. Ten patients (10%) received a single-fraction HDR boost of 8-10.3...

In recent 30 years the understanding of breast cancer surgery (BCS) underwent significant development from radical mastectomy to organ-preserving surgery. So, in nowadays organ-preserving surgery becomes the “gold standart” in these patients. Today, more than half of the newly diagnosed BC are suitable for quadrantectomy or lumpectomy with axillary lymph node dissection and subsequent radiation...

Breast-conserving surgery (BCS) is the treatment of choice for early breast cancer. The adequacy of surgical margins (SM) is a crucial issue for adjusting the volume of excision and for avoiding local recurrences, although the precise definition of an adequate margins width remains controversial. Moreover, other factors such as the biological behaviour of the tumor and subsequent proper systemi...

In 1984, as part of a prior American Cancer Society National Conference on Breast Cancer, the authors reported on the status of conservative surgery (CS) and radiotherapy (RT) as primary local treatment for women with early stage breast cancer. Since that time, additional data have become available regarding the use of this approach and its comparability to mastectomy. In general, these data su...

The study sought to evaluate the quality of life of women treated surgically for breast cancer at the State Oncology Hospital of Reference in São Luís in the State of Maranhão. The quality of life was assessed by the Functional Assessment of Cancer Therapy-Breast (FACT-B). The variables were expressed as mean and standard deviation, and statistical analysis consisted of the ANOVA or Kruskal Wal...

Systemic neo-adjuvant therapy plays a primary role in the management of locally advanced breast cancer. Without having any negative effect in overall survival, induction chemotherapy potentially assures a surgery approach in unresectable disease or a conservative treatment in technically resectable disease and acts on a well-vascularized tumor bed, without the modifications induced by surgery. ...

BACKGROUND There are no effective methods of diagnosis of early-stage ovarian cancer. Conservative care over patients at high risk of ovarian and breast cancers is ineffective. Prophylactic surgery is considered the best prophylaxis among BRCA1/BRCA2 carriers. METHODS One hundred ninety-five patients, carriers of one of three most common mutations of the BRCA1 gene (Am J Hum Genet: 66: (6)196...

tained by milk and nutrient enemata. On the 12th, he could open his mouth to a slight extent ; the symptoms were more favourable, and the spasms had diminished in force and frequency. On passing the flnger into the wound I detected a loose fragment of bone and removed it. The extremity of the lower fragment was sharp or pointed and this I cut off with the saw. From this date he gradually improv...

BACKGROUND Breast augmentation is an elective surgery used to increase the size of the breast in females. This study was undertaken to determine the breast augmentation in Pakistani females. METHODS From 2006 to 2011, 43 female patients who underwent breast augmentation via infra-mammary, periareolar, trans-umbilical and fat transfer were enrolled. For augmentation, saline-filled or gel-fill...

We evaluated local recurrence, toxicity rate and cosmetic outcome in 72 patients treated with high-dose-rate (HDR) brachytherapy after breast conserving surgery. HDR brachytherapy was administered: i) as partial breast irradiation (PBI) in 64 patients with low-risk early stage breast cancer, enrolled in a phase II prospective study; ii) as PBI after a second conservative surgery as treatment of...