Estrogen is a known risk factor in human breast cancer. In rodent models, estradiol has been shown to induce tumors in those tissues in which this hormone is predominantly converted to the catechol metabolite 4-hydroxyestradiol by a specific 4-hydroxylase enzyme, whereas tumors fail to develop in organs in which 2-hydroxylation predominates. We have now found that microsomes prepared from human...

INTRODUCTION Benign Osseous metaplasia of the breast is rare, with only a few cases reported in the literature. Here we present a case of benign osseous metaplasia of the breast presenting as a breast lump. CASE PRESENTATION 38-year-old previously well woman presented with a one-year history of bilateral breast pain and a left-sided breast lump. Ultrasound and mammography suggested calcified ...

A case of a pseudoneoplastic lesion of the breast clinically and sonographically suggestive of a fibroadenoma is reported. Excisional biopsy revealed the nodule was an inflammatory process consequent to infection by Schistosoma mansoni.

A 10 years prepubertal age girl presented duration. Based on the cytological, imaging proliferative breast lesion closest to giant fibroadenoma was offered. in young girls and are difficult to differentiate from low grade phylloides tumor by cytology/ Giant fibroadenomas have to be differentiated from phylloides tumor by the lack of leaf structures and stromal cell atypia and from the breast ha...

The main method of treatment of breast fibroadenomas, until recently, was considered a surgical. However, there is research the authors of a new non-invasive method of treatment HIFU. The paper describes the mechanism of action and clinical features of the effect of treatment of fibroadenomas of the mammary glands by HIFU. Morрhocytology effects confirmation of the method HIFU ablation breast f...

Cross-reactivities among tumor-associated antigens of rat mammary fibroadenomas and among these fribroadenomas and a rat mammary carcinoma were investigated by in vitro techniques. Lymphocytes from five female W/Fu rats bearing mam mary fibroadenomas were found to share a common reactivity against fibroadenoma target cells, as demon strated by lymphocyte cytotoxicity tests on iododeoxyuridine-1...

Introduction Giant juvenile fibroadenomas represent only the 0.5% of all fibroadenomas, constituting a rare condition in adolescence. In prepuberty, the presence of this condition is extremely rare. Presentation of case We describe a rare case of a 12- year-old Caucasian girl who presented to our Hospital complaining of a palpable mass with rapid enlargement in her right breast that she had f...

Benign Breast Diseases, though more frequently responsible for bringing the patient to doctor, have not found many places in good recent researches. lesions of breast assumed increasing importance years because public awareness cancer. These benign lumps are a recognized important risk factor later To study surgical profile with disease This retrospective was conducted at ESIC medical college a...

Fibroadenomas are the most common benign tumor of the br but the peak incidence seen in young adolescent women during the second and third decades of life. Fibroadenoma is a biphasic tumor, composed of an epithelial and a stromal component. Even though they are solitary lesions, multiple fibroadenomas can also occur especially in the older age group. Breast fibroadenomas seemed to display a wid...

The specific mechanism underlying the role of putative stem cell marker aldehyde dehydrogenase 1 (ALDH1) playing in development and progression of breast cancer is currently unclear. Transforming growth factor β (TGFβ) signaling pathway is reported to be activated in most cancers. Thus a study was initiated to explore possible differences and correlation of ALDH1 and TGFβ2 expression in the mos...