the national bridge stock of iran consists of about 330,000 bridges, of which around 50% are older than 30 years. since 2010, iran road maintenance & transportation organization has started implementing a comprehensive bridge management system in order to manage this aged stock efficiently. to predict future conditions of bridge stock, a heuristic numerical method is presented. this methodology...

The main object was to perform simulations using a realistic model of a truck and trailer passing over a flexible bridge structure. The bridge structure was simplified to a flat surface modeled using shell finite elements. Tire normal, lateral and longitudinal forces were applied to the bridge. Three driving cases were considered: straight forward driving with and without braking and a lane cha...

In 2011, the huge tsunami caused by the great east Japan earthquake devastated many infrastructures in pacific coast of north eastern Japan. Particularly, collapse of bridges caused a traffic disorder and these collapse behaviors led to delay of recovery after the disaster. In this study, the bridge wash away accident is selected as a target issue, and it is represented by a numerical simulatio...

Transcriptional coactivators are essential mediators of signal amplification in the regulation of gene expression in response to hormones and extracellular signals. We previously identified Bridge-1 (PSMD9) as a PDZ-domain coregulator that augments insulin gene transcription via interactions with the basic helix-loop-helix transcription factors E12 and E47, and that increases transcriptional ac...

Oscillators are kernel components of electrical and electronic circuits. Discussion of history, mechanisms and design based on Barkhausens observation. Discussion of a Wien Bridge oscillator based on the question: Why does this circuit oscillate ?

Mechanical properties of the myocardium at end diastole have been thought to be dominated by passive material properties rather than by active sarcomere cross-bridge interactions. This study tested the hypothesis that residual cross-bridges significantly contribute to end-diastolic mechanics in vivo and that changes in end-diastolic cross-bridge interaction parallel concurrent changes in systol...

The dynamic behavior of railway bridges carrying high-speed trains can be analyzed with or without the consideration of the vehicle's own structure. However, due to the amount of kinetic energy carried at high speeds, the train may interact significantly with the bridge, especially when resonance occurs. Equally important is the riding comfort and the stability of the track and train cars, whic...

Elastic interaction effect commonly exists in the assembly of multi-bolted joint. It is defined as loss tension forces some bolts due to progressively tightening neighboring bolts. Main cable clamp a large size bolted joint used suspension bridge. Investigation on bolt has seldom been reported. This article presents field experiment study tightening. In experiment, three types and sequences wer...

Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positive) topoisomerase IV through a critical water-metal ion bridge and that the most common quinolone resistance mutations decrease drug activity by dis...

Estimating maximum scour depth is normally required in order to determine the depth of  bridge piles. The present paper uses the SSIIM Software which considers flow and sediment equations in a three dimensional manner. The software models flow field around circular bridge pile by resolving Navier-Stokes three-dimensional equations and k-  method, and by temporary solution of flow field and cont...