UNLABELLED Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation aroun...

BACKGROUND The use of a tourniquet in hand surgery is generally accepted as necessary to create a clear visualization of the operative field. This study aims to determine the effectiveness of one-per-million tumescent solution (1:1,000,000 epinephrine concentration) in creating a bloodless operative field in post-burn hand deformity surgeries performed without a tourniquet. METHODS This retro...

BACKGROUND AND OBJECTIVE There have been several case reports of improvement in the appearance of mature burn scars following treatment with fractional CO(2) lasers. However, the biochemical mechanisms responsible for these improvements have not been elucidated. MATERIALS AND METHODS Ten patients with mature, full-thickness, hypertrophic burn scars received initial treatment with a fractional...

background wound healing is widely discussed in the medical literature. this study compared the healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. methods sixteen rats were randomly assigned to one of two groups, each group 8 rats. a deep second-degree burn on the lower back and 3rd degree burn on upper back of each rat were created with a st...

H ypertrophic scar formation is a major clinical problem in the developing and industrialized worlds. Burn injuries, traumatic injuries, and surgical procedures can give rise to exuberant scarring that results in permanent functional loss and the stigma of disfi gurement. Figure 1 illustrates the scope of the problem. Annually, over 1 million people require treatment for burns in the United Sta...

objective: hypertrophic scar involves excessive amounts of collagen in dermal layer and may be painful. nowadays, we can’t be sure about effectiveness of procedure for hypertrophic scar management. the application of stem cells with natural scaffold has been the best option for treatment of burn wounds and skin defect, in recent decades. fibrin glue (fg) was among the first of the natural bioma...

Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major challenge to scientists and physicians is to prevent adverse scar formation after severe trauma (e.g. burn injury) and understand why some individuals will form adverse scars even after relatively minor injury. Curren...

Healing of burn wounds is often associated with scar formation due to excessive inflammation and delayed wound closure. To date, no effective treatment is available to prevent the fibrotic process. The Renin Angiotensin System (RAS) was shown to be involved in fibrosis in various organs. Statins (e.g. Atorvastatin), Angiotensin receptor antagonists (e.g. Losartan) and the combination of these d...

BACKGROUND In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which will provide the best level of care clinically. Therefore, for paediatric pa...

Background: The optimal therapy for deep burn wounds is based on the early debridement of necrotic tissue followed by wound coverage to avoid a systemic inflammatory response and optimize scar-free healing. outcomes are affected available resources underlying patient factors, which represent challenges in care suboptimal outcomes. In this study, we aimed determine burn-wound management using en...