Many real-world analytics problems involve two significant challenges: prediction and optimization. Due to the typically complex nature of each challenge, the standard paradigm is to predict, then optimize. By and large, machine learning tools are intended to minimize prediction error and do not account for how the predictions will be used in a downstream optimization problem. In contrast, we p...

CA) reveal that DNA is synthesized when it is least likely to be hit with oxidative damage. Damaging oxidizing agents are produced by respiration. In yeast, respiration is periodic—it alternates in ‫ف‬ 40-min cycles with a stage of non-respiration called the reductive phase. This oscillation was detected decades ago, but it was never thought to be connected to cell cycle progression. Now, Kleve...

DEVELOPING a softwareintensive system is like raising a child. As Will PleasantRyan observed, both babies and code have smells, you get used to changing requirements, you have to take the long view, you can’t do it alone, and eventually you have to let go.1 I would add to Will’s most excellent simile that, although you might think you know everything up front, you certainly don’t, and therefore...

"Slime" played a brief and spectacular role in the 19th century founded by the theory of primordial slime by Ernst Haeckel. However, that substance was never found and eventually abandoned. Further scientific attention slowly began in the 1930s referring to slime as a microbial product and then was inspired by "How bacteria stick" by Costerton et al. in 1978, and the matrix material was conside...

A design algorithm is derived, for a calculating minimum allowable electrical clearances in alternating and direct current “permissible” equipments, which are authorized to operate in gassy mines and tunnels under Part 18 of Title 30, Code of Federal Regulations [1]. The calculated clearances apply to operations at altitudes ranging up to 12 000 ft (3658 m) above sea level. The minimum allowabl...

Introduction After the war in Bosnia-Herzegovina that lasted from 1992 to 1995, populations gradually rebuilt their lives haunted by spectrum of personal and collective painful souvenirs. Regarding children who were born after war, some mothers would rather not talk about it protect what they might be feeling while others definetely share have experienced children. Because intergenerational tra...