Multiple osteochondromas (MO) is an autosomal skeletal disease with an elusive molecular mechanism. To further elucidate the genetic mechanism of the disease a three‑generation Chinese family with MO was observed and researched, and a novel frameshift mutation (c.335_336insA) in the exotosin 1 (EXT1) gene of one patient with MO was observed through exome sequencing. This was further validated b...

In the title compound, [Mo(C(5)H(4)NS)(3)(NO)]·2H(2)O, the Mo atom is coordinated by a nitrosyl ligand and three monoanionic N,S-bidentate ligands in a distorted MoN(4)S(3) penta-gonal-bipyramidal mol-ecular geometry. The pyridine N atom of one pyridine-2-thiol-ate (pyt) ligand is coordinated to the Mo atom in the trans position relative to the NO ligand [N(pyt)-Mo-N(NO) = 170.62 (19)°]. The co...

In the title compound, [Mo(C(44)H(28)N(4))(NO(3))O]·C(6)H(6), the porphyrin ring is centrosymmetric. The Mo atom, oxide ion and nitrate ion are equally disordered over two sites, such that the Mo atom is displaced by 0.366 (1) Å towards the oxide ion from the 24-atom mean plane of the porphyrin, and also makes a long Mo-O bond to a nitrate O atom. A centrosymmetric benzene solvent mol-ecule is ...

a,c,d , b c,d * Jeffrey E. Saffitz , Richard B. Schuessler , Kathryn A. Yamada Department of Pathology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Department of Medicine, Washington University School of Medicine, 660 Sout...

The title complex, [Mo(2)(C(13)H(9)N(2)Br(2))(4)]·C(4)H(8)O, contains a quadruply bonded Mo(2) (4+) unit equatorially coordinated by four N,N'-bis-(4-bromo-phen-yl)formamidinate ligands, forming a dimetal paddlewheel complex. The centroid of the Mo-Mo bond is located on a special position with 2/m symmetry. In the crystal, complex mol-ecules are linked by Br⋯Br inter-actions [3.7049 (10) Å]. Th...

The title compound, [Mo(C(10)H(8))(2)], was prepared from the naphthalene radical anion and MoCl(4)(thf)(2) (thf is tetra-hydro-furan). In the crystal, the mol-ecule is located on an inversion center. The Mo atom is equally disordered over two positions; the range of Mo-C distances is 2.2244 (19)-2.3400 (17) Å for both components of the disorder.

The Front Cover shows the gear set of “Homogeneous Catalysis” driven by an engine “M−H−C Agostic Interaction”. critical role agostic interactions in homogeneous catalysis, such as polymerization, C−H bond activation, β-hydride elimination, and cyclometallation, is well-established. Mo−H−C interaction Mo β/γ-agostomers [CpMo(CO)2(PiPr3)]+ Mn−H−C Mn α/ϵ-agostomers [(C6H9]Mo(CO)3] were comprehensi...

A unique method is described for inhibiting nitrogenase. When Clostridium pasteurianum nitrogenase is assayed in the presence of the Mo-Fe protein of Azotobacter vinelandii, all the characteristic activities of nitrogenase are inhibited. C. pasteurianum nitrogenase is unaffected by the Fe protein of A. vinelandii. The Fe protein, but not the Mo-Fe protein of C. pasteurianum, inhibits A. vinelan...

Hyperhomocysteinemia is an independent risk factor for cardiovascular disease in human diabetes. Among the multiple factors that may account for the atherogenicity of homocysteine (Hcys) in patients with diabetes, macrophage (Mo) lipoprotein lipase (LPL) has unique features in that it is increased in human diabetes and acts as a proatherogenic factor in the arterial wall. In the present study, ...

ExposureofheptanesolutionsofMo(NAr)(CHCMe2Ph)(Me2Pyr)(OAr) (1a;Ar=2,6-diisopropylphenyl), Mo(NAr)(CHCMe3)(Me2Pyr)[OCMe(CF3)2] (1b), and Mo(NAr)(CHCMe2Ph)(Me2Pyr)(OSiPh3) (1c) to one atmosphere of ethylene for 12 h yields the ethylene complexes, Mo(NAr)(CH2CH2)(Me2Pyr)(OAr) (2a), Mo(NAr)(CH2CH2)(Me2Pyr)[OCMe(CF3)2] (2b), and Mo(NAr)(CH2CH2)(Me2Pyr)(OSiPh3) (2c). Addition of 1 equiv of triphenyls...