Cadmium is a toxic heavy metal ubiquitously present in the environment and subsequently in the human diet. Cadmium has been proposed to disrupt the endocrine system, targeting in particular the estrogen signaling pathway already at environmentally relevant concentrations. Thus far, the reports on the binding affinity of cadmium towards human estrogen receptor alpha (hERα) have been contradictin...

Since there are a plethora of studies on cadmium toxicity and poisoning in laboratory animals and humans, we have limited this review to studies that are relevant to human health issues by focusing on carcinogenicity, genotoxicity, circulatory disease, nephrotoxicity and life expectancy. Cadmium exposure has been established to induce cancer in various tissues of laboratory animals. Contrary to...

Cadmium has been hypothesized to be a pancreatic carcinogen. We test the hypothesis that cadmium exposure is a risk factor for pancreatic cancer with a population-based case-control study sampled from a population with persistently high rates of pancreatic cancer (south Louisiana). We tested potential dietary and nondietary sources of cadmium for their association with urinary cadmium concentra...

The main objective of the study was to asses whether the environmental cadmium exposure in the Czech Republic is high enough to be able to affect significantly the human reproduction. Cadmium levels were measured in the blood and follicular fluid of 220 women in in vitro fertilization (IVF) therapy, using atomic absorption spectrometry. The mean value of cadmium in venous blood was 0.85 ng x ml...

Cadmium intoxication has been associated with the dysregulation of iron homeostasis. In the present study, we investigated the effect of cadmium on the expression of ferroportin 1 (FPN1), an important iron transporter protein that is involved in iron release from macrophages. When we incubated cadmium with J774 mouse macrophage cells, FPN1 mRNA levels were significantly increased in a dose- and...

The effects of substrate temperature on the structural, optical, medical and electrical characteristics of Cadmium Oxide (CdO) films are investigated in the current study. Films are deposited on glass substrate at different temperatures, ranged between 450–600 oC, using Spray Pyrolysis Technique. According to X– Ray Diffraction (XRD), it is found that the films are polycrystalline and Cadmium O...

Problem statement: Cadmium is one of the most dangerous occupational and environmental toxins. It is found in drinking water, atmospheric air and even in food. Cadmium is reported to be very toxic to biological systems. Until now in treating intoxication with this metal, chelating Compounds have been used, burdened with numerous undesirable symptoms. For this reason, many researches are carried...

Leukotriene (LT) A(4) hydrolase is a bifunctional zinc metalloenzyme, which converts LTA(4) into the neutrophil chemoattractant LTB(4) and also exhibits an anion-dependent aminopeptidase activity. In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center. Here we report that replacement of Arg(563), but not Lys(565), leads to comple...

Male Wistar rats were exposed to a water solution of cadmium chloride (labelled with cadmium-109) at a dose corresponding to 10 mg Cd/kg diet for 28 days. Carcass, hepatic, renal and testicle distribution of cadmium was studied for 32 days after dosing. Our results indicate that the carcass deposition of cadmium was at a comparative level during the experimental period. Hepatic distribution pat...

Cadmium is a nonessential heavy metal and ubiquitous potential environmental pollutant. Although the kidney proximal tubule is an important target for cadmium, the underlying cellular mechanisms of cadmium-induced renal toxicity remain elusive. Numerous studies have demonstrated that cadmium induces apoptotic cell death in various cell types via several apoptotic pathways, including mitochondri...