Autoimmune pancreatic β-cell loss and destruction play a key role in the pathogenesis development of type 1 diabetes, with prospective increased risk for developing micro- macrovascular complications. In this regard, orally administrated verapamil, calcium channel antagonist, usually intended use as an anti-arrhythmic drug, has previously shown potential beneficial effects on preservation new-o...

El Manira, A. and N. Bussières. Calcium channel subtypes in different modulators require further study. Characterization lamprey sensory and motor neurons. J. Neurophysiol. 78: 1334– of the types and properties of calcium channels in identified 1340, 1997. Pharmacologically distinct calcium channels have spinal cord neurons is necessary to provide insight into their been characterized in dissoc...

  The dopaminergic system has different effects on the cardiovascular and immune systems. Since both vascular injuries and activation of the immune system are involved in joint inflammation, in the present study the role of dopaminergic receptors in knee joint inflammation was studied. Evans blue (75 µ g/kg) was used in order to observe changes in permeability which occurred during the process ...

objective(s) four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. the effects of 5a and 5b on angiotensin receptors (at') and l-type calcium channels were investigated on isolated rat aorta. materials and methods aortic rings were pre-contracted with 1 pm angiotensin ii or 80 mm kcl and relaxant effects of losartan, nifedipine, 5a a...

This study investigated the action of the calcium antagonist D600 on calcium channel currents recorded in high barium solution from single, enzymatically isolated smooth muscle cells from the rabbit ear artery using the whole cell configuration of the patch-clamp technique. D600 (1-100 microM) was applied by path perfusion or by a new technique that allowed a concentration jump during the curre...

PURPOSE To explore the role of calcium in morphine withdrawal syndrome using various agents affecting calcium levels in cytoplasm. METHODS Mice were rendered dependent on morphine by subcutaneous injection of morphine, and withdrawal was induced 4 hours later by injecting the opioid antagonist, naloxone. Mice were observed for 30 minutes for signs of withdrawal, ie, characteristic jumping, hy...