background: prostate cancer is one of the most widespread cancers in men and is fundamentally a genetic disease. identifying regulators in cancer using novel systems biology approaches will potentially lead to new insight into this disease. it was sought to address this by inferring gene regulatory networks (grns). moreover, dynamical analysis of grns can explain how regulators change among dif...

background : colorectal cancer is the second cause of mortality in developed countries. the p53gene and some of it's polymorphisms are among the causes for cancer development.the purpose of this study is to evaluate the relationship between the p53 codon 72 polymorphism in colorectal adenocarcinoma specimens compared with controls. materials and methods : we performed a case-control study among...

gene therapy consists of the introduction of genetic material into cells for a therapeutic purpose. the understanding of the basics of the molecular and cellular mechanisms in disease treatments has resulted in the development of high-tech gene transfer materials with improved therapeutic efficacy. based on the results of more than 2000 clinical trials to date, gene therapy is going to be inclu...

objectives : this study sought to assess the effect of low-level laser (lll) on pain and trismus after impacted mandibular third molar surgery. materials and methods : this double blind controlled clinical trial was conducted on 40 healthy patients with no underlying disease and impacted mesioangular mandibular third molars with the same level of difficulty. the patients were divided into two g...

conclusions eudragit coated nanoparticle of chitosan is an efficient choice for oral delivery of dna to upper part of gi tract. results the mean size and zeta potential of particles were 300 ± 4 nm and 14 ± 0.5 mv, respectively. encapsulation of this system was 89.6 ± 1.2%. dna release from batches was less than 12% at ph = 5.2 and more than 60% at ph = 6.8 with significant difference of p < 0....

background type 1 diabetes mellitus is one of the metabolic diseases that cause insulin-producing pancreatic ß cells be destroyed by immune system self-reactive t cells. recent­ly, new treatment methods have been developed including use of the stem cells, ß islet cells transplantation and gene therapy by viral and non-viral gene constructs. objectives the aim of this project was preparing the n...

materials and methods: young adult sprague-dawley rats (200-250g) were assigned into one of the three different groups of control, sci, and adenovirus transfer (ad) (n=3/ group). control rats received no injury, nor any surgery. for sci rats, sci was produced by a 10g brass rod with a tip diameter of 2 mm which was dropped from a height of 12.5 mm onto exposed spinal cord at level of t10 with n...

Abstract Aims Homeobox (HOX) proteins are emerging as promising biomarkers and targets for gene-therapy in cancer; however, their role colorectal liver metastases (CRLM) is unknown. This study aims to investigate the of HOXB9 prognostic marker potential therapeutic target CRLM. Methods Two patient-cohorts were included: a) Patients with cancer (CRC) from National Cancer Institute, Tissue Genome...

Liposomes have attracted great interest as efficient carriers for nutrients, drugs and other bioactive agents as well as ideal models for biological membranes. This article intends to provide an overview of liposomes and nanoliposomes definition as well as their properties and preparation methods. Also it elaborates on various applications of nanoliposomes in nanotherapy including diagnostics, ...