BACKGROUND Geriatric assessment is a multidisciplinary diagnostic process that evaluates the older adult's medical, psychological, social, and functional capacity. No systematic review of the use of geriatric assessment in oncology has been conducted. The goals of this systematic review were: 1) to provide an overview of all geriatric assessment instruments used in the oncology setting; 2) to e...

To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected to enter the oncology field it is relevant to consider the various aspects involved in especially...

BACKGROUND Physicians who provide primary care to women have the opportunity to identify patients at high risk for breast cancer who are candidates for risk reduction strategies. Our objective was to determine the prevalence and determinants of the adoption of breast cancer risk assessment by primary care physicians. METHODS A cross-sectional survey of a nationally representative random sampl...

The estimation of carcinogenic risks from exposure to chemicals has become an integral part of the regulatory process in the United States within the past decade. With it have come considerable controversy and debate over the scientific merits and shortcomings of the methods and their impact on risk management decisions. In this paper we highlight selected topics of current interest in the deba...

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2, associated with Hereditary Breast/Ovarian Cancer syndrome, have up to an 85% lifetime risk of breast cancer and up to a 46% lifetime risk ovarian cancer. Similarly, women with mutations in the DNA mismatch repair genes, MLH1, MSH2 or MSH6, associated with the Lynch/Hereditary Non-Polyposis Colorectal Cancer (HNPCC...

The primary purpose is to do cancer risk assessment of toxaphene by using four steps of risk assessment proposed by the United States National Academy of Sciences/National Research Council (NAS/NRC). Four steps of risk assessment including hazard identification, dose-response relationship, exposure assessment, and risk characterization were used to evaluate cancer risk of toxaphene. Toxaphene w...

BACKGROUND Cancer risk assessment begins in the primary care clinician's office. Essential components of that process include: 1) documentation of personal and family cancer information; 2) identification of families at increased risk for cancer; 3) modification of cancer screening recommendations according to degree of risk; 4) referral of high-risk individuals to cancer genetics clinics. The ...

fault tree analysis (fta) as a probabilistic risk assessment (pra) method is used to identify basic causes leading to an undesired event, to represent logical relation of these basic causes in leading to the event, and finally to calculate the probability of occurrence of this event. to conduct a quantitative fta, one needs a fault tree along with failure data of the basic events (bes). someti...

In recent years, chemical cancer risk assessment has faced major challenges: the demand for cancer risk assessment has grown considerably with strict legislation regarding chemical safety, whereas cancer hazard identification has turned increasingly complex due to the rapid development and high publication rate in biomedical sciences. Thus, much of the scientific evidence required for hazard id...

fractionation studies on the sediment samples provide valuable information on the nature of the metals bound to the sediments. thirty three sediment samples of river adyar were collected during two seasons and speciation study was carried out. the industrial and domestic effluents are directed into the river course at many points in the middle and lower of the adyar river. to ascertain the exte...