Introduction Cancerous tumours are dense populations of uncontrollably dividing cells. All cells require oxygen and nutrient supply as well as waste removal, functions provided by the circulatory system. Therefore tumour growth is affected by vascularity. In order to obtain the blood supply necessary to develop into large, malignant tumours, cancer cells are able to induce blood vessel growth; ...

In this paper, we present a model capable of predicting cancerous and normal state associated to each biological situation using a hybrid system based on genetic algorithms and artificial neural networks. Carried out experiments have shown a very promising results in terms of predictive accuracy and generalization. Besides, the compact set provided by the model includes well known genes include...

In this paper we propose a coupled model for healthy and cancerous cell dynamics in Acute Myeloid Leukemia. The PDE-based model is transformed to a nonlinear distributed delay system. For an equilibrium point of interest, necessary and sufficient conditions of local asymptotic stability are given. Simulation examples are given to illustrate the results.

OBJECTIVE Azadirachta indica (Neem) has been used traditionally for many centuries. Some impressive therapeutic qualities have been discovered. However, the therapeutic effect of neem leaf extract in 4T1 breast cancer has not been documented. The purpose of the present study is to investigate the therapeutic effect of ethanolic Neem leaf extract in an in vivo 4T1 breast cancer model in mice. ...

We are investigating spectroscopic devices designed to make in vivo cervical tissue measurements to detect pre-cancerous and cancerous lesions. All devices have the same design and ideally should record identical measurements. However, we observed consistent differences among them. An experiment was designed to study the sources of variation in the measurements recorded. Here we present a log a...

Neuroendocrine (NE) cells are the minor cell populations in normal prostate epithelial compartments. During prostate carcinogenesis, the number of NE cells in malignant lesions increases, correlating with its tumorigenicity and hormone-refractory growth. It is thus proposed that cancerous NE cells promote prostate cancer (PCa) cell progression and its androgen-independent proliferation, althoug...