Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rar...

BACKGROUND One of the long-term effects in childhood cancer survivors (CCS) is the development of second cancers. In a cohort of CCS, this study describes how second cancers were presented, the way they were diagnosed, and the knowledge CCS had about their increased risk to develop a second cancer. PATIENTS AND METHODS Selected participants were all adult five-year CCS (n = 1275) who were tre...

Evidence shows that continued smoking by cancer patients leads to adverse treatment outcomes and affects survival. Smoking diminishes treatment effectiveness, exacerbates side effects, and increases the risk of developing additional complications. Patients who continue to smoke also have a higher risk of developing a second primary cancer or experiencing a cancer recurrence, both of which ultim...

KRASG12C Somatic Mutations in Various Cancers A survey of more than 32,000 cancers the GENIE registry detected differences distribution mutations various cancer types and i...

background: epidemiologic aspects of oral and pharyngeal cancers in iran have not been studied adequately. we evaluated age-adjusted incidence rates by sex using pathological confirmed cases between 1991 and 2002 in kerman province, south east­ern iran. methods: the information of cases was collected actively from all of the 18 histopathology departments around the prov­ince. the standardize ri...

background cancer is one of the most important leading causes of morbidity and mortality worldwide. objectives this study aimed to calculate the burden of 9 common cancers in the population covered by mashhad university of medical sciences in iran in 2010-2011. patients and methods we calculated disability adjusted life years (dalys ) for each of nine cancers according to the sex and age groups...

Background & Aims: Cancer is a major public health problem in many countries of the world and the third leading cause of death in developing countries. The most frequently diagnosed cancers in females and males are breast and lung cancers respectively. The aim of this study was to investigate the pattern of age distribution and the frequency of different cancers in East Azerbaijan province duri...

background: the fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.the high linear energy transfer (let) of alpha radiation to the targeted cancer cellscauses double strand breaks in dna. at the same time, the short range radiation spares adjacent normal tissues. this targeted approach complements conventional external beam radiotherapy and ch...