Erythropoietin (EPO) exerts its effect on erythroid lineage cells through interaction with the EPO receptor (EPOR), so-called canonical pathway, and a complex consisting of EPOR common cytokine beta subunit (CD131) – non-canonical pathway for non-hematopoietic human animal body. realizes effects launch signaling cascade, which begins phosphorylation Janus kinase 2 (JAK2) then involvement phosphat...

The digital laminae is a two layer tissue that attaches the distal phalanx to the inner hoof wall, thus suspending the horse's axial skeleton in the hoof capsule. This tissue fails at the epidermal:dermal junction in laminitic horses, causing crippling disease. Basal epithelial cells line the laminar epidermal:dermal junction, undergo physiological change in laminitic horses, and lose versican ...

Wnt signaling plays critical biological roles during normal embryonic development and homeostasis in adults. In the canonical pathway, binding of Wnt ligands to the Frizzled (Fzd) receptor and the low density lipoprotein-related receptor (LRP) 5 or LRP6 coreceptor initiates downstream signaling events leading to gene activation by beta-catenin and the T-cell factor (TCF)-lymphoid enhancer facto...

A number of Wnt genes are expressed during, and are known to be essential for, early kidney development. It is typically assumed that their products will act through the canonical β-catenin signalling pathway. We have found evidence that suggests canonical Wnt signalling is not active in the early nephrogenic metanephric mesenchyme, but instead provide expressional and functional evidence that ...

RacGap50C is a Novel Negative Regulator of the Wnt Pathway by Whitney McRae Jones University Program in Genetics and Genomics Duke University Date:_______________________ Approved: ___________________________ Amy Bejsovec, Supervisor ___________________________ John Klingensmith, Committee Chair ___________________________ David McClay ___________________________ Tannishtha Reya _______________...

the famous primary and cyclic decomposition theorems along with the tightly related rational and jordan canonical forms are extended to linear spaces of infinite dimensions with counterexamples showing the scope of extensions.

TNF family members and their receptors contribute to increased gene expression for inflammatory processes and intracellular cascades leading to programmed cell death, both via activation of NF-kappaB. TNF receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor proteins binding to various receptors of the TNFR family. In an attempt to delineate the role of individual TRAFs, we compare...

WNT signalling regulates a variety of cell functions including cell fate, polarity, and differentiation via the canonical or beta-catenin stabilisation pathway and/or the planar cell polarity or non-canonical pathway. We have previously demonstrated that two isoforms (A and B) from the WNT16 locus have differential expression in various adult human tissues. In this study we show that WNT16B but...