BACKGROUND/AIMS Restenosis after a percutaneous coronary intervention (PCI) during treatment for coronary artery disease is closely related to smooth muscle cell (SMC) proliferation and migration. In this study, we investigated the effects of caffeic acid phenethyl ester (CAPE) and its underlying mechanism on human coronary SMCs (HCSMCs) after platelet-derived growth factor-BB (PDGF-BB) stimula...

The ability of climate models to predict extremes is determined by its ability to adequately simulate certain environmental conditions both spatially and temporally. Some of the conditions conducive to the occurrence of extreme weather can be quantified from the convective available potential energy (hereafter referred to as CAPE) and vertical shear of the horizontal wind from 0-6 kilometer (he...

Author details MRC Clinical Trials Unit at UCL, Aviation House, 125 Kingsway, London WC2B 6NH, UK. Global Alliance for TB Drug Development, New York, NY, USA. Department of Mathematical Statistics and Actuarial Science, University of the Free State, Bloemfontein, South Africa. Division of Pulmonology and Department of Medicine, University of Cape Town Lung Institute, Mowbray, Cape Town, South A...

4415 Susceptibility to Fluorescent Light-induced Chromatid Breaks Associated with DNA Repair Deficiency and Malignant Transformation in Culture. Ram Parshad, Katherine K. Sanford, Gary M. Jones, Robert E. Tarone, Harold A. Hoffman, and Alice H. Grier. ':4420 Carcinoembryonic Antigen for Monitoring Patients with Small-Cell Carcinoma of the Lung during Treat ment. T. Phillip Waalkes, Martin D. Ab...

1 Public Health Foundation of India, New Delhi, India, 2 School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa, 3Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4Ghana Health Service/University of Ghana School of Public Health, Accra, Ghana, 5 School of Public Health, Makerere University...

A40 Persistent circulation of highly divergent HIV-1M lineages in the Congo Basin Region M. Tongo, J.R. Dorfman, Tulio de Oliveira, D.P. Martin, Africa Centre for Population Health, University of KwaZulu-Natal, South Africa, Division of Computational Biology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, Institute of Medical Research and Stud...

Center for Macroecology, Evolution and Climate, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark, Department of Biogeography and Global Change, National Museum of Natural Sciences, CSIC, Calle José Gutierrez Abascal 2, 28006 Madrid, Spain, InBio/CIBIO, University of Évora, Largo dos Colegiais, 7000 Évora, Portugal, Metapopulation Research Centre, Department of Bioscienc...

BACKGROUND Propolis and its major constituent - caffeic acid phenethyl ester (CAPE) have good abilities on antitumor and anti-inflammation. However, little is known about the actions of propolis and CAPE on tumor in inflammatory microenvironment, and inflammatory responses play decisive roles at different stages of tumor development. To understand the effects and mechanisms of ethanol-extracted...

1Centre for Human Metabonomics, North-West University, Potchefstroom, South Africa; 2Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa; 3Department of Clinical Laboratory Sciences, Division of Human Genetics & Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town,...

Treatment with amiodarone, a commonly prescribed antidysrhythmic agent, is associated with pulmonary fibrosis (PF) which is a commonly progressive and untreatable disease. Caffeic acid phenethyl ester (CAPE) is a phenolic antioxidant and an active anti-inflammatory , anticancer, antimicrobial and antioxidant component of propolis (bee glue; a resinous hive product collected by honey bees). In t...