BACKGROUND Intracoronary physiology techniques have been validated extensively for the assessment of epicardial stenoses but not for the lone study of coronary microcirculation. We performed a comparison between 4 intracoronary physiological indices with the actual structural microcirculatory changes documented in transplanted hearts. METHODS AND RESULTS In 17 cardiac allograft patients witho...

The capillary action of saliva occurs in the crevices around and between teeth and around dental restorations. Marginal leakage and denture retention caused by a thin film of saliva are aspects of capillary phenomena. Liquids in capillaries isolated from a reservoir showed an increase in surface tension and lower vapor pressure. The strength of thin films of human saliva was independent of ambi...

BACKGROUND Hemodynamic assessment after volume challenge has been proposed as a way to identify heart failure with preserved ejection fraction. However, the normal hemodynamic response to a volume challenge and how age and sex affect this relationship remain unknown. METHODS AND RESULTS Sixty healthy subjects underwent right heart catheterization to measure age- and sex-related normative resp...

BACKGROUND Control of the extracellular fluid volume is one of the most indispensable issues for homeostasis of the internal milieu. However, complex interdependence of the pressures involved in determination of fluid exchange makes it difficult to predict a steady-state tissue volume under various physiological conditions without mathematical approaches. METHODS Here, we developed a capillar...

We demonstrate that a novel high-pressure cell is suitable for fluorescence correlation spectroscopy (FCS). The pressure cell consists of a single fused silica microcapillary. The cylindrical shape of the capillary leads to refraction of the excitation light, which affects the point spread function of the system. We characterize the influence of these beam distortions by FCS and photon-counting...

BACKGROUND In adults, acquired pressure-overload left ventricular hypertrophy can result in myocardial ischemia, which may be due in part to insufficient capillary growth during development of hypertrophy. The coronary microvascular response to congenital pressure-overload hypertrophy in children has not been previously characterized. METHODS AND RESULTS Average capillary density and heteroge...

This paper discusses challenges related to the automatic microinjection of single adherent cells. The discussion covers all necessary components of a capillary pressure microinjection system: a micromanipulator, a microinjector, a microcapillary, a vision system and an environment control system. The other part of the paper describes the research performed on the automatic capillary pressure mi...

Introduction and objective: In 1886, Starling proposed a hypothesis for the capillary–interstitial fluid (ISF) transfer, in which the capillary was thought a tube of a uniform diameter that is impermeable to plasma proteins. The flow of fluid across its wall was thought dependent upon a balance between the hydrostatic pressure within its lumen causing ‘filtration’, and the osmotic pressure of p...

Fourteen patients with acute myocardial infarction were given 0.3 mg sublingual nitroglycerin within the first 12 hours of their acute myocardial infarction. Five minutes after sublingual nitroglycerin mean arterial pressure fell 9 mmHg (1.2 kPa) and remained significantly reduced for 30 minutes. Pulmonary capillary wedge pressure fell from a mean control value of 17 to 12 mmHg (2.3 to 1.6 kPa)...

For more than 50 years, tests of "capillary resistance" have been used to measure the facility with which petechiae may be produced experimentally, mainly with a view to detecting latent purpuric tendencies. Hare and Miller (1951) listed the many different methods which have been evolved, and assessed the merits and demerits of techniques in general use. "Pressure" tests, such as the snake veno...