Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...

children under 3 years of age must not travel in a car or goods vehicle (other than a taxi) unless restrained in the correct child seat. children aged 3 years or over who are under 150 cm in height and weighing less than 36 kilograms must use the correct child seat, booster seat or booster cushion. rearward-facing child car seats must never be used in the front passenger seat of cars with an ac...

The digital factory concept is an integrated approach to enhance the product and production engineering processes and simulation is a key technology in digital factory concepts. Different types of simulation can be applied in virtual models on various planning levels and stages to improve the product and process planning. In an advanced stage simulation can be used in the digital factory concep...

The uncertainty of the theoretical prediction of the B̄ → Xsγ branching ratio at NLL level is dominated by the charm mass renormalization scheme ambiguity. In this paper we calculate those NNLL terms which are related to the renormalization of mc, in order to get an estimate of the corresponding uncertainty at the NNLL level. We find that these terms significantly reduce (by typically a factor o...

This paper describes the integration of an experience factory in a modelbased risk analysis framework called CORAS. CORAS aims at developing a new model-based risk analysis framework for security critical application. The framework’s cornerstone of combining methods for risk analysis of critical systems and semiformal modelling methods in a tool-supported environment targeting openness and inte...

FactoryDef : DPDef name = "Abstract Factory" L1 : LevelDef AF : RoleDef name = "Abstract Factory" L2 : LevelDef L3 : LevelDef CF : RoleDef name = "Concrete Factory" AP : RoleDef name = "Abstract Product" L4 : LevelDef CP : RoleDef name = "Concrete Product" root

This paper explores the use of an Agent Factory for the composition of web services. Previous work proposed a structuring approach for automated reconfiguration of agents by an Agent Factory. The question is whether the same approach can be applied to web service composition, i.e. whether DAML-S descriptions of web services offer enough structure for automated configuration by the Agent Factory...

In order to fulfill all challenges related to design, management, evaluation and reconfiguration of new or existing facilities, the development of a new, integrated and holistic factory framework is required. In this context, a new requirements model is proposed in the context of the innovative framework called Virtual Factory Framework. Using this approach in factory planning it is expected to...

We present a summary of the experimental issues, detector design and plans from the Third Workshop on the Tau-Charm Factory, Marbella, 1–6 June 1993. Presented at the Third Workshop on the Tau-Charm Factory Marbella, Spain, 1–6 June 1993 EXPERIMENTAL ASPECTS OF THE TAU-CHARM FACTORY Jasper Kirkby CERN, Geneva, Switzerland Abstract We present a summary of the experimental issues, detector design...

survivors of car accidents not only are physically challenged, but also from psychological trauma, such as post-traumatic stress disorder (ptsd) also suffers. in recent years, ptsd disorder and other psychological reactions is increased after an accident. ptsd is a disorder with special signs after stressful events such as accidents can be seen psychological. ptsd is common responses that peopl...