A suppository for rectal administration of carbamazepine has been developed for situations in which it is unsuitable to use the oral route of administration. In an open, controlled, within-patient study, the pharmacokinetics, clinical efficacy, and tolerability of carbamazepine slow-release tablets were compared with those of carbamazepine suppositories in children with epilepsy. The pharmacoki...

Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34-year-old female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient's symptoms responded rapidly with antihistamine therapy and w...

Intracranial section of the glossopharyngeal and upper roots of the vagus nerves has been recommended, the cardiac dysrhythmia being controlled with atropine, isoprenaline, or transvenous pacemaker. Carbamazepine is known to relieve the pain of uncomplicated glossopharyngeal neuralgia.2 In our first patient the combination of carbamazepine and demand pacemaker abolished both pain and syncope wi...

We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine. Soon after the introduction of carbamazepine, EEGs began to worsen, and finally absence seizures and myoclonic seizures appeared. Immediately after we discontinued carbamazepine, the seizures disappeared and the EE...

AIMS AND METHODS Alcohol withdrawal treatment efficacy of tiapride/carbamazepine (A) vs clomethiazole (B) vs diazepam (C) in non-intoxicated patients and vs tiapride/carbamazepine in intoxicated patients (D; breath alcohol concentration > or = 1 g/l) was tested (n = 127) in a controlled randomized open-label study. RESULTS Efficacy and safety were not different between groups (total group: de...

Acute interstitial pneumonia or diffuse alveolar damage is uncommon as an adverse reaction to carbamazepine therapy. We report the case of a 36 yr old woman, who developed respiratory failure after auto-intoxication with carbamazepine. Analysis, including bronchoalveolar lavage and lung tissue biopsy, suggested diffuse alveolar damage due to carbamazepine.

Objective(s): Fasted rodents treated with antimuscarinics develop convulsions after refeeding. Food deprivation for 48 hr produces changes in [3H]glutamate binding suggesting glutamatergic contribution to the underlying mechanism of the seizures that are somewhat unresponsive to antiepileptics. Studies in animals and epileptic patients yielded considerable information regarding the anticonvulsa...

background: it is still a challenge to find an effective treatment for tinnitus. the aim of this study was the evaluation of carbamazepine and oxcarbazepine effects on tinnitus. methods: in a randomized double-blind clinical trial, 57 patients who were visited in a university hospital due to chronic non-pulsatile tinnitus, were randomized in three groups and treated with carbamazepine (300-600 ...

background: we investigated the effects of carbamazepine (cbz) on semen parameters in men with newly diagnosed epilepsy, by performing semen analysis before starting any antiepileptic drugs, and then after starting cbz, to determine the role and effects of cbz in creating abnormalities in sperm analysis in these patients. methods: in this prospective study, eight male patients 20-40 years of ag...