We carried out a theoretical study to investigate the thermodynamics and the kinetics of the activation of the anticancer drug carboplatin in a carbonate buffer, a process which has been suggested to play an important role in the uptake, antitumor activity and toxicity of this drug. The initial stages of this process have been investigated by considering both the carbonate and the bicarbonate i...

This research studies freeway ramp merging phenomena under congested traffic situation via a Driving Simulator (DS). The main objectives of this study were to initially develop a traffic simulation, which evaluates the capacity of merging section relevant to the geometric design and the flow condition. Furthermore, to form a pilot system of the DS combined with the simulation, from which the dr...

Ramp meters in the Twin Cities have been turned off for eight weeks in fall 2000 in an experiment testing their effectiveness. This chapter analyzes the data collected during the experiment on several representative freeways during the afternoon peak period. Several performance measures for ramp metering including mobility, equity, consumers’ surplus, productivity, accessibility, and travel tim...

Ramp meters in the Twin Cities have been the subject of a recent test of their effectiveness, involving turning them off for eight weeks. This paper analyzes the results with and without ramp metering for several representative freeways during the afternoon peak period. Seven performance measures: mobility, equity, productivity, consumers’ surplus, accessibility, travel time variation and trave...

The purpose of this study was to investigate traffic flow characteristics at off-ramp junctions in Iranian expressways. The study was conducted on the traffic behavior in isolated off-ramp vicinity of 6-lane expressways. The database consisted of traffic flow and traffic speed information extracted from videotapes. The relationship between diverging traffic flow in the right lane of expressway ...

Ramp metering has been broadly accepted and deployed as an effective countermeasure against both recurrent and non-recurrent congestion on freeways. However, many current ramp metering algorithms tend to improve only freeway travels using local detectors' inputs and overlook the negative impacts on local streets. This may generate two problems: 1) the optimal local settings may not result in a ...

The late Smithian and the Smithian-Spathian boundary (SSB) are associated with harsh environmental conditions, including abrupt temperature changes, oceanic acidification oxygen deficiency causing an additional marked loss of biotic diversity in aftermath end-Permian mass extinction. Such disturbances documented worldwide through large fluctuations C, O, S N biogeochemical cycles. This study pr...