نتایج جستجو برای: carboxylcytosine
تعداد نتایج: 116 فیلتر نتایج به سال:
269 ABSTRACT Ten-eleven translocation (TET) proteins oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). 5fC and 5caC can be excised and repaired by the base excision repair (BER) pathway, implicating 5mC oxidation in active DNA demethylation. Genome-wide DNA methylation is erased in the transition from metastable states to the...
Role for tet in hyperglycemia-induced demethylation: a novel mechanism of diabetic metabolic memory.
During germ cell and early embryonic development— the most sensitive and vulnerable period of epigenetic reprogramming—exposure to an adverse environment leads to abnormal methylation and, possibly, long-term health problems. DNA methylation, a major epigenetic mechanism for gene silencing, is recognized to be responsible for the stability of gene expression status. The majority of cytosine-pho...
Introduction.Many transcription factors initiate transcription only in specific sequence contexts, providing the means for sequence specificity of transcriptional control. A four-letter DNA alphabet only partially describes the possible diversity of nucleobases a transcription factor might encounter. For instance, cytosine is often present in a covalently modified form: 5-methylcytosine (5mC). ...
•UHRF2 is physically and functionally associated with the BER complex•UHRF2 allosterically activated by 5hmC to catalyze K33-linked XRCC1 ubiquitination•XRCC1 ubiquitination aids its interaction RAD23B TDG incorporation into BER•UHRF2-fostered TDG-RAD23B-BER assembly promotes completion of DNA demethylation The transition oxidized 5-methylcytosine (5mC) intermediates base excision repair (BER) ...
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