Low-dose aspirin is widely used in the primary and secondary prevention of cardiovascular events, but is associated with a range of upper gastrointestinal side effects. In this review, we summarize the rationale for low-dose aspirin therapy, quantify the risk for upper gastrointestinal side effects, identify the risk factors involved, and provide an overview of preventive strategies, thereby fo...

The amount of transfused dimethyl sulfoxide (DMSO) is indicated as the major cause of the cryoprotectant-related toxicity in autologous stem cell recipients, with a high incidence of major cardiac side effects. In this study we tried to discover whether fractionated infusion of the total graft volume could prevent the DMSO-related major cardiovascular side effects. We conclude that continuous c...

Clozapine is known to cause innocuous as well severe and or fatal cardiovascular side effects. These effects are commonly reported at the initiation of clozapine therapy. We report a patient who was stable on for several years but in whom we had withhold medical reasons subsequently developed significant hypotension heart rate changes when rechallenged with small dose clozapine.

Side weirs are flow diversion devices that are widely used in irrigation, drainage and urban sewage systems. The present study focuses on the investigation of the effect of oblique side weirs on the discharge coefficient of a side weir under subcritical flow condition in rectangular channels. In this study 106 laboratory tests were conducted and the results were analyzed to find out the influen...

Cardio-vascular specialists have witnessed and actively participated in the revolutionary developments that have occurred in their field of specialization over the last few years. Cutting-edge technologies have led to dramatic improvements in life-expectancy and quality of life. An open-mind and pioneering attitude are necessary when exploring new frontiers to improve our patients’ health. Howe...

BIOCHEMICAL DERANGEMENTS resulting from adrenal cortical hyperfunction or from critical reduction of the endogenous corticosteroid hormone supply are sometimes overshadowed by major disturbances of cardiovascular function. Arterial hypertension and congestive heart failure may be the predominanit presenting clinical features in patients with adrenal cortical hyperfunction. During acute illness ...

Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimer's disease (AD), but their cholinergic effects could generate adverse side effects in the cardiovascular system. This report presents the cases of 2 patients who experienced adverse side effects of cardiac rhythm with QT prolongation caused by Donepezil. Both of them improved to the original rh...

The modelling aim in this study was to explore the relationship between plasma concentrations of a cardiovascular drug nitrendipine and occurrences of its side effects. The data were taken from a bioequivalence study in 40 men with a 20 mg single dose of nitrendipine. During the study occurrences of side effects, their severity, onset time and duration were recorded. Overall, side effects occur...

S INCE most congenital cardiovascular malformations are probably a result of complex interactions between genetic and environmental factors, racial comparisons may provide clues to the etiologic factors involved. In a retrospective study, Hernandez and associates' suggested that the frequency of coarctation of the aorta was low in American Negroes, although others have disputed this observation...