In recent years, l-carnitine has been used increasingly as a supplement in livestock animals. The present review gives an overview of the effects of dietary l-carnitine supplementation on the reproductive performance of sows. Results concerning the effect of l-carnitine supplementation during pregnancy on litter sizes are controversial. There are some studies reporting an increased number of pi...

Early feed restriction of lambs promotes a permanent mitochondrial dysfunction that impairs efficiency along the whole life. Dietary L-carnitine, compound plays an essential role in energy metabolism transferring long-chain fatty acids to mitochondria for subsequent β-oxidation, has demonstrated positive effects (e.g., improved markers or muscle/heart function) early restricted lambs. The purpo...

l-Carnitine is a vitamin-like amino acid derivative, which is an essential factor in fatty acid metabolism as acyltransferase cofactor and in energy production processes, such as interconversion in the mechanisms of regulation of cetogenesis and termogenesis, and it is also used in the therapy of primary and secondary deficiency, and in other diseases. The determination of carnitine and acyl-ca...

This study has been initiated to investigate whether endogenous carnitine depletion and/or carnitine deficiency is a risk factor during development of cisplatin (CDDP)-induced cardiomyopathy and if so, whether carnitine supplementation by propionyl-L-carnitine (PLC) could offer protection against this toxicity. To achieve the ultimate goal of this study, a total of 60 adult male Wistar albino r...

an experiment was conducted to study the effects of soybean, linseed and sunflower oil (various sources of fatty acids) with and without l-carnitine supplements (0 and 50 mg kg-1) on performance, blood biochemical parameters and carcass traits of japanese quail. one hundred and ninety-two of 7-day old female japanese quail were randomly assigned to 6 dietary treatments with 4 replicates and fed...

Carnitine (3-hydroxy-4-trimethylammonio-butanoate), an essential cofactor for mitochondrial long-chain fatty acid oxidation, is synthesized in mammals, and consequently is present in diets containing meat products. When the diet does not contain carnitine rats and man appear to produce sufficient carnitine to maintain homoeostatis. Carnitine is the product of the essential amino acids lysine an...

Background: L-carnitine is an essential compound that facilitates the transport of long-chain fatty acid across the inner mitochondrial membrane for β-oxidation. However, the effect of L-carnitine supplementation remains to be fully explored in patients with chronic kidney disease. We aimed in this study to determine the multidirectional effects of L-carnitine supplementation on clinical parame...

Transarterial chemoembolization (TACE) is usually followed by hepatic dysfunction. We evaluated the effects of L-carnitine on post-TACE impaired liver functions. Methods. 53 cirrhotic hepatocellular carcinoma patients at Osaka Medical College were enrolled in this study and assigned into either L-carnitine group receiving 600 mg oral L-carnitine daily or control group. Liver functions were eval...

We have previously reported that weanling rats fed a 20% wheat gluten diet, limiting in lysine and containing no detectable carnitine, have significantly lower levels of carnitine in skeletal and heart muscle than rats receiving adequate dietary lysine. Rats on 20% wheat gluten diets were administered appropriate levels of DL-[6-i*C]lysine, L-[mefhyZ3H]methionine, t-N-[mefhyZ-3H]trimethyl-L-lys...

Carnitine is necessary for transport of long-chain fatty acids into mitochondria, to enter the beta-oxidation cycle. Four carnitine cycle defects have been described. The carnitine transporter mediates carnitine transport across the plasma membrane. Symptoms include hypoketotic hypoglycaemia and cardiomyopathy. Some affected subjects are asymptomatic. Newborn screening detects very low levels o...