Dioxins enter the body through the diet and cause various toxicological effects through transformation of an aryl hydrocarbon receptor (AhR). Plant extracts and phytochemicals including flavonoids are reported to suppress this transformation. This paper investigates the suppression by a cacao polyphenol extract (CPE) of AhR transformation in vivo. The CPE was administered orally to C57BL/6 mice...

Cocoa is a rich source of polyphenols that has been traditionally used as the treatment of several types of inflammation related disease. The response to inflammation comprises the consecutive release of mediators and the enlistment of circulating leukocytes, such as macrophages. Currently, Cocoa-derived polyphenolics have shown anti-inflammatory effects in vivo, but the therapeutic benefits in...

The seed of Cycas pectinata is widely used in traditional practices the Northeastern region India for diverse purposes along with improving testicular functions. Thus, it may be hypothesized that phytochemicals C. could modulate steroidogenesis. Therefore, we have investigated effects Pectinata extract (CPE) on steroidogenesis by using vivo and vitro approaches. We also performed molecular dock...

Date palm seed (Phoenix dactylifera) (DPS) extract has been used worldwide in pharmaceutical agent due to its constituents. This study aimed to assess the effects of DPS extract as a dietary supplementation at on the body composition, lipid peroxidation and tissue quality of common carp (Cyprinus carpio) based on the total volatile nitrogen (TVN) test. Common carp juveniles weighing ca 32 g wer...

BACKGROUND The hypothalamic-pituitary-gonadal (HPG) axis is critical in the development and regulation of reproduction in fish. The inhibition of neuropeptide gonadotropin-releasing hormone (GnRH) expression may diminish or severely hamper gonadal development due to it being the key regulator of the axis, and then provide a model for the comprehensive study of the expression patterns of genes w...

The widespread prevalence of diabetes, caused by impaired insulin secretion and insulin resistance, is now a worldwide health problem. Glucagon-like peptide 1 (GLP-1) is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. Prolonged activation of the GLP-1 signal has been shown to attenuate diabetes in animals and human subjects. Therefore, GLP-1 secretagog...

Collagenase-dispersed carp pituitary cells in a perifusion system were used to study the role of calcium ions in the mechanism of GnRH action on the release of maturational gonadotropin (GtH) in fish. The specific calcium chelator EGTA and the calcium antagonist manganese (Mn2+) caused a 40% inhibition in the basal GtH release and completely blocked GnRH-stimulated GtH release. Short-term appli...

The electroanalytical determination of avidin in solution, in a carbon paste, and in a transgenic maize extract was performed in acidic medium at a carbon paste electrode (CPE). The oxidative voltammetric signal resulting from the presence of tyrosine and tryptophan in avidin was observed using square-wave voltammetry. The process could be used to determine avidin concentrations up to 3 fM (100...

The present study focuses on the role of Costus pictus extract (CPE) against the oxidative stress caused by hypeglycemia in liver and kidney of alloxon administered rats.Hyperglycemic rats were administered with two dose levels(200 and 400mg/kg body weight) of CPE for 30 days.At the end of treatment,blood glucose,serum marker enzymes alanine amino transfrease(ALT),aspartate amino transferase(AS...

Adult female rats were rendered anovulatory by continuous illumination. Pituitary LH of these constant estrous rats decreased with the time length of illumination. Acidic extract from the rat hypothalamus was injected into these rats through the carotid artery for testing LH-RF activity. The extract, if a dose more than 2 hypothalamic fragments per rat was given, induced ovulation. Ovulatory re...