An expeditious assembling of fused poly-heterocyclic structures having a N(Acyl), N(aryl)-Acetal core has been accomplished by cascade reaction ortho-functionalized anilines with 2-formylbenzonitrile and subsequent intramolecular N-amidic cyclization on different electrophilic carbons. The syntheses have finalized using both cathodically-initiated conventional base-catalyzed methods comparing t...

In this study, we combined the ChIP-seq and the transcriptome data and integrated these data into signaling cascades. Integration was realized through a framework based on dataand model-driven hybrid approach. An enrichment model was constructed to evaluate signaling cascades which resulted in specific cellular processes. We used ChIP-seq and microarray data from public databases which were obt...

In this paper is presented a discussion of fission induced in heavy elements (uranium) by protons with kinetic energies below about 400 MeV with the main emphasis on fission with protons of a few hundred MeV energy *. Thus, reactions where meson interference becomes of any importance are not considered. Even if fission is the main reaction in heavy nuclei this can not be discussed without consi...

The word-of-mouth diffusion has been regarded as an important mechanism to advertise a new idea, image, technology, or product in online social networks (OSNs). This paper studies the prediction of popular and viral image diffusion in Pinterest. We first characterize an image cascade from two perspectives: (i) volume – how large the cascade is, i.e., total number of users reached, and (ii) stru...

A novel and convenient approach to the synthesis of various phosphorated indolines via a copper-catalyzed radical cascade cyclization reaction has been developed. The reaction employs cheap copper as the catalyst and K2S2O8 as the oxidant under mild conditions. Various alkenes and P-radical precursors are compatible with this transformation. Preliminary mechanistic studies reveal that the addit...

The production of butanol, acetone and ethanol by Clostridium acetobutylicum is a biphasic fermentation process. In the first phase carbohydrate substrate metabolized to acetic butyric acid, in following second product spectrum shifted towards economically interesting solvents. Here we present cascade six continuous stirred tank reactors (CCSTR), which allows performing time dependent metabolic...

Abstract The origin and evolution of magnetic fields neutron stars from birth have long been a source debate. Here, motivated by recent simulations the Hall cascade with helicity, we invoke model where large-scale field grows as product small-scale turbulence through an inverse cascade. We apply this to simulated population at show how can account for such objects across <m...

Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through hydrogen-atom transfer (HAT) and use tailor-made ketimines as reliable electrophilic partners. This transformation translated into an controlled radical/polar ca...