Three large open pool fire experiments involving a calorimeter the size of a spent fuel rail cask were conducted at Sandia National Laboratories’ Lurance Canyon Burn Site. These experiments were performed to study the heat transfer between a very large fire and a large cask-like object. In all of the tests, the calorimeter was located above the center of a 7.93m diameter fuel pan, elevated 1m a...

In Caenorhabditis elegans, mutations in the lin-2 gene inactivate the LET-23 receptor tyrosine kinase/Ras/MAP kinase pathway required for vulval cell differentiation. One function of LIN-2 is to localize LET-23 to the basal membrane domain of vulval precursor cells. LIN-2 belongs to the membrane-associated guanylate kinase family of proteins. We have cloned and characterized the human homolog o...

Presynaptic voltage-gated calcium (Ca(2+)) channels mediate Ca(2+) influx into the presynaptic terminal that triggers synaptic vesicle fusion and neurotransmitter release. The immediate proximity of Ca(2+) channels to the synaptic vesicle release apparatus is critical for rapid and efficient synaptic transmission. In a series of biochemical experiments, we demonstrate a specific association of ...

A numerical simulation of flow and heat transfer in a ventilated concrete dry storage cask system–17 (VSC–17) is performed and results compared with experimental data to assess the validity of the computational approach. The measurements of steady state temperature distributions on the cask surface, concrete surface, air flow channels, and fuel canister guide are available. Numerical simulation...