Herpes simplex virus 1 (HSV-1) was shown to contain catalase, an enzyme able to detoxify hydrogen peroxide by converting it to water and oxygen. Studies with a catalase inhibitor indicated that virus-associated catalase can have a role in protecting the virus from oxidative inactivation. HSV-1 was found to be more sensitive to killing by hydrogen peroxide in the presence of a catalase inhibitor...

BACKGROUND Catalase (EC 1.11.1.6) is one of the important industrial enzyme employed in diagnostic and analytical methods in the form of biomarkers and biosensors in addition to their enormous applications in textile, paper, food and pharmaceutical sectors. The present study demonstrates the utility of a newly isolated and adapted strain of genus Geobacillus possessing unique combination of sev...

Catalase is resistant to oxidizing agents; e.g., ferricyanide. It is also resistant to reducing agents; e.g., catalytically activated hydrogen, hydrosulfite, ferrotartrate, cysteine. The hemin group of the enzyme will combine with cyanide, sulfides, nitric oxide, fluoride. It will not combine with carbon monoxide. Catalase is therefore a ferric complex. The stability of the ferric iron in the e...

Microbodies are enzyme-containing organelles bounded by a single unit membrane and lacking DNA. The family includes peroxisomes, glyoxysomes and glycosomes. The organelles have a variety of metabolic functions, none of which is present in all members: beta-oxidation of fatty acids, the glyoxylate cycle, alcohol oxidation, and even glycolysis have been found confined within microbodies. Animal c...

Annau, E., Banga, I., Blazso, A., Brukner, V., Laki, K., Straub, F. B. & Szent-Gyorgyi, A. (1936). Hoppe-Seyl. Z. 244, 105. Annau, E., Banga, I., Gozsy, B., Huszak, S., Laki, K., Straub, F. B. & Szent-Gyorgyi, A. (1935). Hoppe-Seyl. Z. 236, 1. Annau, E. & Erd6s, T. (1939). IHoppe-Seyl. Z. 257, 111. Banga, I., Ochoa, S. & Peters, R. A. (1939). Biochem. J. 33, 1980. Das, N. B. (1937a). Biochem. J...

Superoxide dismutase, catalase, glutathione peroxidase and peroxiredoxins form an antioxidant network protecting cells against reactive oxygen species (ROS). Catalase is a potent H2O2-detoxifying enzyme, which is unexpectedly absent in some members of the Kinetoplastida and Apicomplexa, but present in Toxoplasma gondii. In T. gondii, catalase appears to be cytosolic. In addition, T. gondii also...

The irreversible inhibition of catalase by 3-amino-l, 2,4-trizole and a group of related inhibitors (1) in the presence of a continuous supply of hydrogen peroxide has been shown to result from a reaction of the inhibitors with catalase-hydrogen peroxide complex I (2) in which 1 mole of inhibitor is incorporated into the enzyme protein for each mole of catalase heme that has reacted (1). The ki...

The catalase-ethyl hydrogen peroxide compound studied by Stern (1) formed slowly, even in the presence of a very large concentration of ethyl hydrogen peroxide. In the previous paper (2), Stern’s compound has been shown to be preceded by a green primary compound. These kinetic studies show that the primary compound forms rapidly, has a high affinity* for its substrate, and quantitatively fulfil...

The catalase-ethyl hydrogen peroxide compound studied by Stern (1) formed slowly, even in the presence of a very large concentration of ethyl hydrogen peroxide. In the previous paper (2), Stern’s compound has been shown to be preceded by a green primary compound. These kinetic studies show that the primary compound forms rapidly, has a high affinity* for its substrate, and quantitatively fulfil...

Sublethal heating of Staphylococcus aureus produced little loss of catalase activity, but incubation of the injured cells in tryptic soy broth, with or without 10% NaCl added, produced an 85% decrease in catalase activity. Cells recovered in tryptic soy broth demonstrated increases in catalase levels after approximately 5 h, whereas in tryptic soy broth with 10% NaCl the levels remained low for...