نتایج جستجو برای: catenin
تعداد نتایج: 19104 فیلتر نتایج به سال:
-Catenin is a cytoplasmic protein that participates in the assembly of cell-cell adherens junctions by binding cadherins to the actin cytoskeleton. In addition, it is a key component of the Wnt signaling pathway. Activation of this pathway triggers the accumulation of -catenin in the nucleus, where it activates the transcription of target genes. Abnormal accumulation of -catenin is characterist...
Wnt signaling pathways have fundamental roles in animal development and tumor progression. Here, employing Xenopus embryos and mammalian cell lines, we report that the degradation machinery of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating β-catenin. For example, in common with β-catenin, exogenous expression of destruction com...
beta-Catenin is the nuclear effector of the Wnt signaling cascade. The mechanism by which nuclear activity of beta-catenin is regulated is not well defined. Therefore, we used the nuclear marker RanGTP to screen for novel nuclear beta-catenin binding proteins. We identified a cofactor of chromosome region maintenance 1 (CRM1)-mediated nuclear export, Ran binding protein 3 (RanBP3), as a novel b...
We studied the effect of N-cadherin, and its free or membrane-anchored cytoplasmic domain, on the level and localization of beta-catenin and on its ability to induce lymphocyte enhancer-binding factor 1 (LEF-1)-responsive transactivation. These cadherin derivatives formed complexes with beta-catenin and protected it from degradation. N-cadherin directed beta-catenin into adherens junctions, and...
As part of the E-cadherin-β-catenin-αE-catenin complex (CCC), mammalian αE-catenin binds F-actin weakly in the absence of force, whereas cytosolic αE-catenin forms a homodimer that interacts more strongly with F-actin. It has been concluded that cytosolic αE-catenin homodimer is not important for intercellular adhesion because E-cadherin/αE-catenin chimeras thought to mimic the CCC are sufficie...
BACKGROUND The role of TCF/β-catenin signalling in T cell development is well established, but important roles in mature T cells have only recently come to light. METHODOLOGY/PRINCIPAL FINDINGS Here we have investigated the signalling pathways that are involved in the regulation of β-catenin in primary human T cells. We demonstrate that β-catenin expression is upregulated rapidly after T cell...
Hepatocellular carcinoma (HCC) represents a serious public health challenge with few therapeutic options available to cancer patients.Wnt/β-catenin pathway is thought to play a significant role in HCC pathogenesis. In this study, we confirmed high frequency of CTNNB1 (β-catenin) mutations in two independent cohorts of HCC patients and demonstrated significant upregulation of β-catenin protein i...
P-88: Assessing Expression Changes of Some Wnt Pathway Genes During Goat Early Embryonic Development
Background: The developmental competency of embryos is affected by several factors, including the developmental pathways and their elements. In mammalian species including goat, fertilized oocyte undergoes several divisions to form a structure called blastocyst. These events depend on the successful control of temporal and spatial expression of genes involved in genome activation. One of the cr...
Hypoxic exercise exerts a significant effect on body weight loss and fat reduction. Methods: In the present study, we constructed an obese rat model divided rats into following groups: Normoxic quiet (C), (H), Exercise (CE), (HE). We employed isobaric tags for relative absolute quantification (iTRAQ) using proteomic technology to screen differentially expressed proteins in four groups. Addition...
To explore the protective effect of bilobalide on pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. simulate ischemia-reperfusion condition, was The cells were divided into control, and deprivation/ reperfusion+bilobalide groups. viability, proliferative capacity, malondialdehyde level, superoxide dismutase apoptosis, Wnt1 protein level nuclear beta-cateni...
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