. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . doi:10.1093/eurheartj/ehp500 Online publish-ahead-o...

T he intensive care unit (ICU) is an extremely stressful environment where anxiety is prevalent, pain frequent, rest difficult, and sleep often impossible. Relief of pain and anxiety is often neglected while efforts focus on immediate life-threatening concerns. A growing awareness of ICU imposed stress and the increasing popularity of some modes of mechanical ventilation such as extended ratio ...

We describe an infant with stridor associated with gastroesophageal reflux (GER). This is the first report in which there is clear documentation by pH probe of a temporal association between individual episodes of GER and stridor. We review the literature and speculate on the relationship between these two phenomena. GER should be considered in patients with stridor.

Copyright © 2007 AHC Signaling of nerve growth factor (NGF) and its receptor (TrkA) promotes neuronal differentiation, synapse formation and survival. It has been known that the complex of NGF and TrkA is internalized into the cytoplasm and transported for further signal transduction, but the ultrastructural information of this process is virtually unknown. In order to clarify the relationship ...

The multidrug ATP-binding cassette, subfamily G, 2 (ABCG2) transporter was recently identified as an important human urate transporter, and a common mutation, a Gln to Lys substitution at position 141 (Q141K), was shown to cause hyperuricemia and gout. The nature of the Q141K defect, however, remains undefined. Here we explore the Q141K ABCG2 mutation using a comparative approach, contrasting i...

OBJECTIVE Aggregation and deposition of amyloid beta (Abeta) in the brain is thought to be central to the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that cerebrospinal fluid (CSF) Abeta levels are strongly correlated with AD status and progression, and may be a meaningful endophenotype for AD. Mutations in presenilin 1 (PSEN1) are known to cause AD and change Abeta levels....

Authors: S. Wessel and M. Troyer http://ArXiv.org/cond-mat/0505298 Phys. Rev. Lett. 95, 127205 (2005); Authors: D. Heidarian and K. Damle http://ArXiv.org/cond-mat/0505257 Phys. Rev. Lett. 95, 127206 (2005); Authors: R. G. Melko, A. Paramekanti, A. A. Burkov, A. Vishwanath, D. N. Sheng, and L. Balents http://ArXiv.org/cond-mat/0505258 Phys. Rev. Lett. 95, 127207 (2005). Authors: R. G. Melko, A....

BACKGROUND The clinical and hematologic features of β-thalassemia are modulated by different factors, resulting in a wide range of clinical severity. The main factors are the type of disease-causing mutation and the ability to produce α-globin and γ-globin chains. In the present study we investigated the respective contributions of known modifiers to the prediction of the clinical severity of β...

Pseudonannolene lundi n. sp., is described from Lapa Sem Fim Cave, a limestone cave from Luislândia municipality, Minas Gerais State, Brazil. The species is the eighth troglobitic millipede and the third of the genus Pseudonannolene described from Brazilian caves. Pseudonannolene lundi shows pronounced depigmentation and decrease of body size, as found in other troglobitic species belonging to ...