Crimean-Congo hemorrhagic fever (CCHF) virus is the cause of an important tick-borne disease of humans throughout regions of Africa, Europe, and Asia. Like other members of the genus Nairovirus, family Bunyaviridae, the CCHF virus M genome RNA segment encodes the virus glycoproteins. Sequence analysis of the CCHF virus (Matin strain) M RNA segment revealed one major open reading frame that pote...

Aim: This study aims to determine whether Crimean–Congo Hemorrhagic Fever (CCHF) has effects on abdominal vascular structures.
 Material and Method: The group included 35 patients diagnosed with CCHF. control symptoms such as dyspepsia, pelvic pain, pain who underwent multidetector computed tomography (MDCT) whose MDCT examinations were reported completely normal. is a retrospective admitt...

BACKGROUND Crimean-Congo haemorrhagic fever (CCHF) is a potentially fatal tick-borne infection. The virus is widely distributed around the world and reports of sporadic cases and outbreaks have recently increased significantly. Some authors have proposed that ribavirin improves survival in CCHF and this view appears to be widely accepted. METHODS We evaluated the efficacy of ribavirin in redu...

BACKGROUND Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is a zoonotic virus transmitted by Ixodid ticks and causes Crimean-Congo hemorrhagic fever (CCHF) disease in humans with up to 50 % mortality rate. METHODS Freshly slaughtered livestock at the Kumasi abattoir in the Ashanti Region of Ghana were examined for the presence of ticks once a month over a 6-month period from May to November 2...

sequences clustered within the Europe/ Turkey clade. The genetic distance between the 2 strains was 1.15%, but the 2 sequences were identical at the amino acid level. Sequences from the present study showed 96.4%–98.8% similarity with respective CCHFV sequences from Bulgaria from a former study (BUL10/02 and BUL1/03) (3) but differed from the Kosovo 9553/2001 strain by 0.8%–2.0% and from the Gr...

BACKGROUND Although there have been a number of studies on the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) recently, knowledge on this topic is still insufficient. This study aims to reveal the kinetics of serum CCHF virus (CCHFV) titers, serum levels of anti-CCHFV immunoglobulin (Ig)G, tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, and interferon (IFN)-γ in CCHF patients....

Crimean-Congo hemorrhagic fever (CCHF) virus is a serious human pathogen causing severe hemorrhagic disease with a fatality rate of up to approximately 30%. We have determined the viral genomic sequence from an isolate that caused a fatal case of imported CCHF in the United Kingdom in October 2012.

AIM Crimean-Congo hemorrhagic fever is a potentially fatal viral disease in humans caused by CCHF virus. We aimed to demonstrate change in serum levels of matrix metallopeinase/tissue matrix metalloproteinase inhibitor (MMP/TIMP) associated with CCHF. PATIENTS AND METHODS Blood specimens were collected in acute and convalescence periods from the patients presented to Cumhuriyet University Hos...

First described as a clinical entity in 1994–1995, Crimean-Congo Hemorrhagic Fever (CCHF) is currently present in many regions of Africa, Asia, the Middle East, and Europe [1]. Annually, >1000 reported CCHF cases result in fatality rates ranging from 10% to as high as 50% in endemic regions [2]. The history of CCHF in Iran goes back to 1970, when 45 of 100 sheep sera sent from Tehran to Moscow ...

Introduction: Livestock is a known source of Crimean-Congo Hemorrhagic Fever (CCHF) virus infection in humans. Although CCHF is endemic in Iran, limited human cases of CCHF are reported from northwest of Iran. Considering the lack of complete and updated information on the status and distribution of CCHF infection among domestic animals in Ardabil province, this study was conducted to investiga...