INTRODUCTION CCN4, also termed WNT-inducible signaling pathway protein-1 (WISP-1), has important roles in inflammation and tissue injury. This study aimed to investigate the effect of CCN4 inhibition using monoclonal anti-CCN4 antibody (CCN4mAb) on the liver injury and fibrosis in a mouse model of liver fibrosis. MATERIAL AND METHODS The mouse liver fibrosis model was induced by carbon tetrac...

PURPOSE Retinal pigment epithelial (RPE) cells have an important role in the immune suppression associated with the immune privilege of the eye. Some aspects of this remain unclear and this study aimed to determine how RPE cells could influence the production of chemokines by T lymphocytes. METHODS T lymphocytes, separated from peripheral blood of normal volunteers, and RPE cells, cultured fr...

BACKGROUND Ginseng essence (GE) is a formulation comprising four medicinal and edible herbs including ginseng (Panax ginseng), American ginseng (Panax quinquefolius), lotus seed (Nelumbo nucifera), and lily bulb (Lilium longiflorum). This study was aimed at investigating the hepatoprotective effect of GE against carbon tetrachloride (CCl4)-induced liver injury in rats. METHODS We treated Wist...

The aim of this study is to investigate the effect of alcoholic and aqueous extracts of Nigella sativa seeds on the reproductive values, some sexual hormones level and histological change of treated and normal male mice at one spermatogenesis cycle (five weeks). Sixty albino Swiss male mice were used as animal model, they divided into six groups equally, and 1st group served as control group, t...

CCl4-induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl4 metabolites to cell components and/or peroxidative damage as the cause of injury. (1) Covalent binding of 14C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl4. (2) Low oxygen partial pressure increased the reductive meta...

The effect of pentoxifylline (PTX) on acute liver injury caused by CCl4 or acetaminophen was studied in the rat. PTX was given twice daily (18, 36 or 72 mg/kg), intraperitoneally (ip) for 5 days prior to CCl4 or acetaminophen. In addition, the effect of PTX administered simultaneously with CCl4 or acetaminophen was evaluated. Rats were killed 72 h or 48 h after CCl4 or acetaminophen administrat...

Few data are available in the literature regarding the effect of pentosan polysulfate (PPS) on normal and fibrotic rat livers. In addition, the combination of PPS and carbon tetrachloride (CCl4) has not been studied so far. The objective of this study was to assess the effect of PPS on rat livers treated or not with CCl4 for the induction of liver fibrosis. The study consisted of four stages: 1...

Luffa cylindrica (Linn) commonly called sponge gourds has both medicinal and nutritional properties. It is used traditionally for the management of liver diseases. Herein, we investigated hepatoprotective effect crude methanol extract L. fruit in rats chronically exposed to carbon tetrachloride (CCl4). Male were CCl4 twice a week six weeks was administered five times weeks. Markers toxicity, an...

The present study is aimed to evaluate the hepatoprotective effects of leaves and flower extracts of ervatamia coronaria against CCl4 induced hepatic damage. The results indicated that both flower and leaves extract of ervatamia coronaria exhibited significant effect against CCl4 induced hepatic damage. We also observed the restoration of elevated levels liver marker enzymes includes SGOT,SGPT,...

Article history: Received on: 14/07/2016 Revised on: 17/08/2016 Accepted on: 02/09/2016 Available online: 28/12/2016 Background/Aim: The liver is continuously linked to the gut via the portal vein supply. Gastrointestinal complications are directly associated with liver cirrhosis. Carbon tetrachloride (CCl4) caused liver toxicity is well documented in animal models, the very fewer search has be...