Pleurotus cornucopiae (PC) mushrooms are found in the field and commonly known in Japan as Tamogidake mushrooms. The present study investigated the protective effects of an aqueous extract of PC on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanism involved in this protection including cytochrome P450 (CYP) 2E1. Wistar rats were pretreated with aqueous extracts of PC ...

The effect of ISP-I/myriocin on adenosine 3′monophosphate (3′-AMP) forming enzyme activity in carbon tetrachloride (CCl4)-induced hepatitis was examined. The 3′-AMP forming enzyme activity in mouse liver was enhanced by the treatment of CCl4. The increase in the activity in cytosol may result from the leakage of the enzyme from mitochondria via the damage of mitochondrial membrane induced by CC...

The aim of this study was to determine whether calcium potentiates acute carbon tetrachloride (CCl4) -induced toxicity. Elevated calcium levels were induced in mice by pre-treatment with cholecalciferol (vitamin D3; V.D3), a compound that has previously been shown to induce hypercalcemia in human and animal models. As seen previously, mice injected with CCl4 exhibited increased plasma levels of...

AIM The aim of this study was to investigate the antioxidant and hepatoprotective effects of the polyherbal formulation (PHF)containing Cajanus cajan (L.)Millsp., Lawsonia inermis L. Linn, Mimosa pudica L., Uraria picta (Jacq.)DC. and Operculina turpethum (L.)Silva Manso on carbon tetrachloride (CCl4)induced acute liver damage in albino rats. MATERIALS AND METHODS The groups of animals were a...

Objective: To evaluate the hepatoprotective potential of methanol extract of roots and rhizomes of Smilax zeylanica L on carbontetrachloride (CCl4) induced hepatotoxicity in Wistar albino rats. Methods: Hepatotoxicity was induced in Wistar albino rats of either sex by administration of CCl4 0.5 ml/kg p.o. once a day for 7 days. The methanol extract of roots and rhizomes of Smilax zeylanica L we...

The Hepatoprotective and antioxidant activity of pet ether, methanol and aqueous extracts of aerial parts (except fruites) of Cicer arietinum L against ccl4 induced hepatotoxicity in rats. The phytochemical investigations of these extracts showed presence of carbohydrates, proteins, phenols and flavanoids. LD50 values of all extracts were determined. The extracts did not produce any mortality e...

In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Among them some compounds have shown significant antihepatotoxic...

in order to investigate the effects of peppermint (mentha piperita l.) alcoholic extract on liver injury caused by the oxidant carbon tetrachloride (ccl4), an experiment was performed as a completely randomized design in a factorial arrangement (2 × 2) with 4 replications of 10 broilers each. factors included two levels of peppermint leaf alcoholic extract (0 and 2 ml/kg body weight) and ccl4 (...