Tyrosine kinase inhibitors (TKIs) are the standard of care for patients with metastatic non-small cell lung cancers (NSCLC) harbouring epidermal growth factor receptor mutations (EGFRm). However, role TKIs is not established in management stage III EGFRm disease. We describe real-world practice testing and use NSCLC KINDLE study, a multicentre, multi-country observational non-interventional stu...

Angiotensin-converting enzyme 2 (ACE2), the functional receptor of SARS-CoV-2, plays a crucial role in pathogenesis COVID-19. ACE2 targeting holds promise for preventing and inhibiting SARS-CoV-2 infection. In this work, we describe development use test system based on competitive ELISA primary screening potential antiviral compounds. We studied activity library dyes different groups. Several (...

Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has been shown to inhibit HIV infection and has been applied in clinical treatment of AIDS. The recent development that chemokines and chemokine receptors play important roles in HIV infection led us to investigate the possible functional interaction of TCS with chemokine...

Heart failure remains a huge societal concern despite medical advancement, with an annual direct cost of over $30 billion. While guideline-directed therapy (GDMT) is proven to reduce morbidity and mortality, many eligible patients heart reduced ejection fraction (HFrEF) are not receiving one or more the recommended medications, often due suboptimal initiation titration in outpatient setting. Ho...

Epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors (TKI) have transformed traditional cancer treatment and brought good news to patients with non-small cell lung cancer. However, drug resistance problems arise one after another. Based on further exploration of the mechanism EGFR corresponding therapeutic strategies, author reviewed relevant literature, classified summarized it,...

Several anti-cancer drugs are known to have immunomodulatory effects, including immunogenic cell death (ICD) of cancer cells. ICD is a form apoptosis which caused by the release damage-associated molecular patterns (DAMPs), uptake antigens dendritic cells, and activation acquired immunity against was originally reported in solid tumors, there been few reports on multiple myeloma (MM). Here, we ...

Klopman described the chemical reaction of metal ions and base in term softness, E‡n E‡m, respectively. By simple modification known methods, Singh et al. made it applicable for neutral Lewis acids (transition salts) bases (organic molecules) also extended its application to biological systems site selectivity explain mechanism (markovnikov anti-markovnikov rule), ligand-receptor interaction te...

Monocyte chemotactic protein-1 (MCP-1) interacts with the chemokine receptor CCR2. Two CCR2 cDNAs have been described. Sequence analysis as well as Northern blotting and RNase protection with different probes revealed that the CCR2 gene is expressed in activated natural killer (NK) cells and mononuclear phagocytes as a predominant long transcript (3.4 kb) consisting of CCR2B followed by a novel...

This literature review presents data on the influence of serotonin metabolism bone tissue. The mechanisms by which affects formation and resorption bone, depending site synthesis (central or peripheral), as well cells receptor subtypes that are activated, have been considered. A number issues for further research highlighted, in particular, dose-response relationship side effects during chronic...