C-C chemokine receptor 5 (CCR5) is a major co-receptor molecule used by HIV-1 to enter cells. This led the hypothesis that stimulating an antibody response would block HIV with minimal toxicity. Here, X-ray crystallographic studies of anti-CCR5 RoAb13 together two peptides were undertaken: one peptide 31-residue containing PIYDIN sequence and other PIDYIN alone, where part N-terminal region CCR...

A woman at 41 weeks’ gestation presented to our hospital in December, 2009, in labour. She had a history of intravenous drug use, and was unaware of her HIV status. Rapid HIV-1 testing was positive and she had high viral load. A small-for-gestational-age boy was delivered vaginally, in good condition. 12 h after his birth virological analyses, comprising HIV 1-2 antibody western blot (gag, pol,...

chemokine and chemokine receptors show several variations which may affect resistance to infectious disease. a 32 base pair deletion in the open reading frame of the human ccr5 gene (ccr5?32) results in producing a truncated antigen which fails to be presented on the surface of target cells. ccr5?32 variant is not a functional co receptor for hiv-1 entrance and delay the onset of acquired immun...

What is it famous for? It's not really, but whenever science policy is discussed in the UK media, government, or in industry, it's a fair bet that Save British Science (SBS) will be in the fray. SBS is the leading lobby group for science in the UK. The 'science' it aims to save includes any activity that develops and applies scientific understanding, including medicine, mathematics, engineering...

Chemokine receptor tyrosine sulfation plays a key role in the binding of chemokines. It has been suggested that is heterogeneous, but no experimental evidence provided so far. The potent anti-HIV chemokine analog 5P12-RANTES proposed to owe its inhibitory activity capacity bind larger pool cell surface CCR5 receptors than native chemokines such as CCL5, molecular details underlying this phenome...

It is by now established that neutrinos mix, have (different) non-zero masses, and therefore oscillate. The oscillation parameters themselves, however, are not all well-known. An open problem is that of the neutrino mass hierarchy. We study the possibility of determining the neutrino mass hierarchy with atmospheric neutrinos using an iron calorimeter detector capable of charge identification su...