Potential domain-domain docking residues, identified from the x-ray structure of the Clostridium symbiosum apoPPDK, were replaced by site-directed mutagenesis. The steady-state and transient kinetic properties of the mutant enzymes were determined as a way of evaluating docking efficiency. PPDK mutants, in which one of two stringently conserved docking residues located on the N-terminal domain ...

background: to evaluate relation between air pollution and rate of flare and   hospital admission among ibd patients. methods: during a 10 months period, the number and average duration of hospitalization of patients admitted in gi ward due to ibd flare were recorded in an industrial capital city. concomitantly the level of 4 major air pollutants including so2, co, no2 and o3 measured and the c...