Background Plasmacytoid dendritic cells (pDCs) are crucial mediators of the immune system linking innate and adaptive responses [1]. pDCs exhibit high expression IL-3 receptor (CD123) as well other receptors such BDCA-2 (CD303) BDCA-4 (CD304). These molecules used to identify in mechanistic studies for therapeutic targeting. A recent clinical trial showed a reduction interferon-stimulated gene ...

Background: Dendritic cells (DCs) are known to contribute the pathogenesis of different autoimmune diseases. It is clear nowadays role DCs in rheumatoid arthritis (RA) but not well investigated Axial spondylitis (AxSpA). a heterogeneous population and can be divided into groups: myeloid (mDCs) plasmacytoid (pDCs). induce both immune response tolerance. Objectives: To investigate subpopulations ...

Background T cell immunotherapy is one promising approach to improve outcomes for patients with AML; however, infused T cells do not redirect resident T cells to tumors. To overcome this, we have genetically modified T cells to produce a secretable, bispecific T cell engager (ENG-T cells). Consistent synthesis of engagers by T cells should be superior to the direct infusion of the recombinant b...

Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid dendritic cell precursor. Cases of HN that completely lack CD4 or CD56 expressio...

Differential diagnosis between plasmacytoid dendritic precursor cell leukemia (pDC leukemia) and acute myeloid leukemia (AML) with monocytic differentiation is difficult due to shared clinicopathological features ; however, such diagnosis is critical because the two leukemias are treated differently. Here we report a peculiar case of AML mimicking pDC leukemia. A 22-year-old man presented with ...

We report here a novel strategy to redirect oncolytic adenoviruses to CD123 by carry a soluble coxsackie-adenovirus receptor (sCAR)-IL3 expression cassette in the viral genome to form Ad.IL3, which sustainably infected acute myeloid leukemia (AML) cells through CD123. Ad.IL3 was further engineered to harbor gene encoding manganese superoxide dismutase (MnSOD) or mannose-binding plant lectin Pin...

Recovery of dendritic cells (DCs) and natural killer (NK) cells after allogeneic stem cell transplantation (SCT) is important for allograft responses and antitumor immunity and thus for treatment outcome. Regulation of this regenerative process is not well understood. We investigated the influence of endogenous cytokines on the recovery and diversification of DC and NK cell subsets up to 6 mont...