In healthy carriers of human cytomegalovirus (HCMV), the virus-specific memory CD8(+) T-cell population is often dominated by CD28(-) CD45RA(hi) cells that exhibit direct ex vivo cytotoxicity but whose capacity for proliferation and generation of further memory cells has been questioned. We show that when highly purified CD28(-) CD45RA(hi) CD8(+) T cells are stimulated with viral peptide presen...

We investigated the expression of CD99 in 35 hyperplastic perigastric lymph nodes, which were resected for gastric carcinoma or chronic peptic ulcer. Essentially, all lymphocytes in lymph nodes expressed CD99, but there were two populations with respect to the intensity of CD99 expression--CD99high and CD99low cells. We showed CD99high cells were distributed in paracortical and medullary cords ...

BACKGROUND SPARC is a matricellular protein involved in tissue remodelling, cell migration and angiogenesis, while forkhead box P3 (FOXP3) protein functions as a transcription factor involved in immune cell regulation. Both SPARC and FOXP3 can play an anti-tumorigenic role in cancer progression. The aim was to determine if SPARC, FOXP3, CD8 and CD45RO expression levels are associated with color...

Adoptive tumour immunotherapy using human CD4+ T-cells Sir-We read with interest the article by Nakamura et al. describing the generation of large numbers of CD4+CD45RO+ helper/killer T-cells for potential use in adoptive tumour immunotherapy. It is these cells that form the basis for autolymphocyte therapy (ALT). As previously reported, ALT is adoptive tumour immuno-therapy based upon the infu...

Alterations in blood lymphocyte subsets may be involved in the development of overt myeloma. Naive (CD4+CD45RA+) and memory (CD4+CD45RO+) helper T-cell subsets are important effectors of immune T-cell regulation. We analyzed the distribution of these blood lymphocyte subpopulations in patients with monoclonal gammopathies, considering the type of disorder, clinical stage, and treatment status.