Background:Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity, which is highly invasive. Verrucous carcinoma (VC) is the low-grade form of SCC. Epithelial dysplasia (ED) also has a malignant potential. This immunohistochemical (IHC) study aimed to assess angiogenesis and the presence of tumor-associated macrophages (TAMs) in SCC, VC and ED to determi...

PURPOSE The role of macrophages in tumorigenesis is complex because they can both prevent and promote tumor development. EXPERIMENTAL DESIGN Four hundred forty-six colorectal cancer specimens were stained with the pan-monocyte/macrophage marker CD68, and average infiltration along the tumor front was semiquantitatively evaluated using a four-grade scale. Each section was similarly scored for ...

Reprogramming of glucose metabolism in tumor cells is referred to as the Warburg effect and results in increased lactic acid secretion into the tumor microenvironment. We have previously shown that lactic acid has important roles as a pro-inflammatory and immunosuppressive mediator and promotes tumor progression. In this study, we examined the relationship between the lactic acid concentration ...

OBJECTIVES Ki-67 is expressed in the nuclei of dividing cells and can be used to assess proliferation of synovial inflammatory and stromal cells. We evaluated subintimal Ki-67+ cell density as a tissue biomarker for inflammatory arthropathies and compared it to subintimal CD68, a synovial biomarker of RA. METHODS Subintimal Ki-67+ and CD68+ cell densities were measured immunohistochemically i...

PURPOSE Macrophages are migratory cells that are frequently recruited to the site of tumors. Their presence is associated with poor clinical outcome in a variety of epithelial malignancies. The aim of this study is to examine the prognostic significance of tumor-associated macrophages in sarcomas. EXPERIMENTAL DESIGN Global gene expression profiling data of a series of soft tissue tumors were...

Objective: This study investigated the expression of chemotactic factor CCL5 in gastric cancer tissue and its correlation with macrophage marker CD86. Methods: Fifty patients diagnosed with gastric cancer in our hospital from Jan 2015 to Dec 2016 were selected. Pathological tissue samples were tested. Results: The expression levels of CCL5 and CD68 correlate with tumour size, degree of tumour i...

AIM To detect the immunohistopathology of necrotising scleritis. METHODS Immunohistochemical staining was performed on two groups of enucleated eyes with necrotising scleritis (systemic autoimmune disease and idiopathic scleritis). Deparaffinised sections were stained with CD3, CD20, CD68, CD8, CD4 and dendritic reticulum cells (DRC). RESULTS Within the autoimmune group, about 43% of inflam...

Intimal hyperplasia limits the durability of peripheral vascular interventions and is associated with cell proliferation macrophage infiltration. We use an in vivo rat carotid angioplasty model to evaluate inhibition intimal localized siRNA delivery targeting Thrombospondin-2 (TSP2) its impact on (Ki-67) infiltration (CD68). was induced by Fogarty catheter vessel injury common artery 32 rats, w...

Background. Classical Hodgkin lymphoma is characterized by a minority of neoplastic cells surrounded by a heterogeneous background population of non-neoplastic cells including lymphoma associated macrophages. High levels of expression of both the monocytes/macrophage lineage associated antigens CD68 and CD163 have been suggested to have protumoral effects. The aim of our study was to correlate ...