Fluorescent probe produced in scavenging reaction of OH by Coumarin-3-carboxyl acid (CCA) can be measured sensitively. It was aimed to apply CCA solution to estimation of the dependence of the OH yield on LET and scavenging time. Heavy ions of energies up to 28GeV from HIMAC were taken for irradiation.

The interplay of CD4(+) and CD8(+) T cells targeting autoantigens is responsible for the progression of a number of autoimmune diseases, including type 1 diabetes mellitus (T1D). Understanding the molecular mechanisms that regulate T cell activation is crucial for designing effective therapies for autoimmune diseases. We probed a panel of Abs with T cell-modulating activity and identified a mAb...