Abstract Single-cell omics is the fastest-growing type of genomics data in literature and public repositories. Leveraging growing repository labeled datasets transferring labels from existing to newly generated will empower exploration single-cell data. However, current label transfer methods have limited performance, largely due intrinsic heterogeneity among cell populations extrinsic differen...

The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approaches are showing promise in their abilities to uncover these mysteries. Here w...

The RCSB Protein Data Bank (PDB) offers online tools, summary reports and target information related to the worldwide structural genomics initiatives from its portal at http://sg.pdb.org. There are currently three components to this site: Structural Genomics Initiatives contains information and links on each structural genomics site, including progress reports, target lists, target status, targ...

Fibroblast activation is a hallmark feature of pathological remodeling the heart and represents an attractive target for therapeutic intervention. Pharmacological inhibition chromatin enzymes reduces cardiac fibrosis, but underlying transcriptional regulatory mechanisms remain poorly understood. Using single-cell genomics to profile alterations in landscape during stress-induced remodeling, Ale...