HIV serodiscordant couples are an extremely useful tool for examining immune responses that may contribute to reduced transmission or protection from HIV infection. A homozygous 32-base pair deletion in the gene encoding the Chemokine receptor 5 protein (CCR5) is strongly associated with protection from HIV infection (Huang et al., 1996). In contrast, the contribution of humoral, cellular and i...

Glycoconjugate is one of the most efficacious and safest vaccines against bacterial pathogens. Previous studies of glycoconjugates against pathogen E. coli O157:H7 focused more on the humoral responses they elicited. However, little was known about their cellular responses. In this study, we exploited a novel approach based on bacterial protein N-linked glycosylation system to produce glycoconj...

Abstract There is limited knowledge of influenza‐specific immune responses and their kinetics in critically ill patients. We investigated humoral cellular after critical influenza A/H1N1 infection hypothesized that dysfunctionality or absence could contribute to more severe illness. followed 12 patients hospitalized with infection; the majority admitted intensive care unit (ICU). Blood samples ...

Chemically induced tumors in mice provide a system to investigate tumor-associated antigens (TAA). The cell surface glycoprotein antigens on such tumor cells have been identified as suitable targets for immune attack. The induction of immune responses against (TAA) in N-nitrosodiethylamine (DEN) exposed mice has been examined. In order to present antigens to the immune system, the liposome was ...