To explore the control of thyroid hormone metabolism in brain during maturation, we have measured iodothyronine deiodination in homogenates of rat cerebrum, cerebellum, and hypothalamus from 1 d postnatally through adulthood. Homogenates were incubated with (125)I-l-thyroxine (T(4)) + [(131)I]3,5,3'-l-triiodothyronine (T(3)) + 100 mM dithiothreitol. Nonradioactive T(4), T(3), and 3,3',5'-triiod...

Drug abuse has been claimed to cause the loss of neurons and reduction of volume in both the adult and developing brain. This study examined cortex volumes in cerebrum and cerebellum of male rats that were dependent on morphine using unbiased stereological counting methods and systematic random sampling technique. Our goal was to test whether short time exposure to morphine can affect the corte...

The cortico-ponto-cerebellar system is one of the largest projection systems in the primate brain, but in the human brain the nature of the information processing in this system remains elusive. Determining the areas of the cerebral cortex which contribute projections to this system will allow us to better understand information processing within it. Information from the cerebral cortex is conv...

By J. N. (BERRY, M D., M.R.C.P., D.C.H. (From the MediwrlrCollege Hospital, Nagpur, India) Hypotonia in cerebral diplegia is relatively are and when present is often associated with choreo-athetotic movements and is present in the peripheral segments in between tonic spasms. Cases with marked inco-ordination and hypotonia are due to a cerebellar component. Wilson (1940) divides such cases into ...

We report a patient with acute cerebral infarction of the left paramedian thalamus, upper mesencephalon and cerebellum who exhibited ipsilateral oculomotor nerve palsy and contralateral downbeat nystagmus. The site of the infarction was considered to be the paramedian thalamopeduncular and cerebellar regions, which are supplied by the superior cerebellar artery containing direct perforating bra...

BACKGROUND AND PURPOSE Correlation of MRI findings with atherosclerotic vascular lesions has rarely been attempted in patients with cerebellar infarction. The aim of this study was to correlate the MRI lesions with the vascular lesions seen on conventional cerebral angiography in cerebellar infarction. METHODS The subjects included 31 patients with cerebellar infarcts who underwent both MRI a...

PURPOSE To correlate imaging abnormalities, clinical features, and postmortem findings in patients with proved cerebral malaria. MATERIALS AND METHODS Twenty-one patients aged 17-50 years with cerebral malaria consented to undergo transverse nonenhanced (10-mm sections) and contrast material-enhanced (8-mm sections in posterior fossa and 10-mm sections in supratentorial region) CT on admissio...

Differences in cerebellar structure have been identified in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and developmental dyslexia. However, it is not clear if different cerebellar regions are involved in each disorder, and thus whether cerebellar anatomical differences reflect a generic developmental vulnerability or disorder-specific characteristics. To cl...

BACKGROUND Recent studies have addressed the role of structures other than the basal ganglia in the pathophysiology of craniocervical dystonia (CCD). Neuroimaging studies have attempted to identify structural abnormalities in CCD but a clear pattern of alteration has not been established. We performed whole-brain evaluation using voxel-based morphometry (VBM) to identify patterns of gray matter...