نتایج جستجو برای: cerebral cortex methamphetamine neurotoxicity

تعداد نتایج: 292796  

Journal: :caspian journal of neurological sciences 0
mohammad-reza semnani farhad mashayekhi mahnaz azarnia department of cell and molecular biology, school of biological sciences, kharazmi university, tehran, iran; [email protected] zivar salehi

background: the cuprizone multiple sclerosis (ms) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. it has been shown that green tea epigallocatechin-3-gallate (egcg) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. objective...

2011
Kunio Doi Koji Uetsuka

Among many mycotoxins, T-2 toxin, macrocyclic trichothecenes, fumonisin B(1) (FB(1)) and ochratochin A (OTA) are known to have the potential to induce neurotoxicity in rodent models. T-2 toxin induces neuronal cell apoptosis in the fetal and adult brain. Macrocyclic trichothecenes bring about neuronal cell apoptosis and inflammation in the olfactory epithelium and olfactory bulb. FB(1) induces ...

Journal: :Experimental neurology 2004
Matthew J LaVoie J Patrick Card Teresa G Hastings

Previous studies have demonstrated methamphetamine (METH)-induced toxicity to dopaminergic and serotonergic axons in rat striatum. Although several studies have identified the nature of reactive astrogliosis in this lesion model, the response of microglia has not been examined in detail. In this investigation, we characterized the temporal relationship of reactive microgliosis to neuropathologi...

Journal: :iranian biomedical journal 0
ملیحه نوبخت maliheh nobakht سیدمحمد حسینی seyed mohammad hoseini پژمان مرتضوی pejman mortazavi ایرج سهرابی iraj sohrabi بنفشه اسماعیل زاده banafshe esmailzade ناهید رهبر روشندل nahid rahbar rooshandel شیلا امید ظهیر

background: alzheimer’s disease (ad) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. the aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of ad. methods: adult male albino wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. the rats were randomly assigned t...

2015
Ali Reza Khalatbary Elmira Ghaffari Behrooz Mohammadnegad

BACKGROUND Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. METHODS Rats were randomly divided into four groups each containin...

Journal: :Addiction 2011
Helenna Nakama Linda Chang George Fein Ryan Shimotsu Caroline S Jiang Thomas Ernst

BACKGROUND Methamphetamine (Meth) abuse continues to be a major illicit drug of abuse. Neuroimaging findings suggest that Meth is neurotoxic and may alter various brain structures, but the effect of Meth on the aging brain has not been studied. AIM The aim was to determine regional volumes of cortical gray matter in the brains of adult Meth users versus healthy control subjects, and their int...

Journal: :Journal of drug abuse 2016
Robert Malcolm Hugh Myrick Xingbao Li Scott Henderson Kathleen T Brady Mark S George Ronald E See

BACKGROUND Neuroimaging of drug-associated cue presentations has aided in understanding the neurobiological substrates of craving and relapse for cocaine, alcohol, and nicotine. However, imaging of cue-reactivity in methamphetamine addiction has been much less studied. METHOD Nine caucasian male methamphetamine-dependent subjects and nine healthy controls were scanned in a Phillips 3.0T MRI s...

1997
Victor Villemagne Jie Yuan Dean F. Wong Robert F. Dannals George Hatzidimitriou William B. Mathews Hayden T. Ravert George A. Ricaurte

The present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (DA) neurotoxicity in baboons and to ascertain whether positron emission tomography (PET) imaging with the DA transporter (DAT) ligand [C]WIN-35,428 ([C]2b-carbomethoxy-3b-(4-fluorophenyl)-tropane) could be used to detect methamphetamine-induced DAT l...

Journal: :AJNR. American journal of neuroradiology 1991
C L Truwit C P Denaro J R Lake T DeMarco

Neurotoxicity is a recognized complication of cyclosporin A (CsA) therapy in patients undergoing organ transplantation. It is most commonly manifested by fever, seizures, and altered mental status. Cortical blindness and speech and motor disturbances can also occur. Changes seen in cerebral white matter on imaging studies are nonenhancing areas of hypoattenuation on CT and T2 prolongation on MR...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Paul M Thompson Kiralee M Hayashi Sara L Simon Jennifer A Geaga Michael S Hong Yihong Sui Jessica Y Lee Arthur W Toga Walter Ling Edythe D London

We visualize, for the first time, the profile of structural deficits in the human brain associated with chronic methamphetamine (MA) abuse. Studies of human subjects who have used MA chronically have revealed deficits in dopaminergic and serotonergic systems and cerebral metabolic abnormalities. Using magnetic resonance imaging (MRI) and new computational brain-mapping techniques, we determined...

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