background and objectives : streptococcus pneumoniae is the main causative agent of acute bacterial meningitis in the world. this study aimed to detect pneumoniae infection in cerebrospinal fluid (csf) samples of patients with suspected meningitis. materials and methods : in this study, 200 csf samples in patients with suspected meningitis and with negative bacterial cultures were tested. demog...

An 89-year-old male presented with cerebrospinal fluid (CSF) rhinorrhea associated with head trauma sustained as a pedestrian in a traffic accident. Computed tomography (CT) showed pneumocephalus and multiple cranial bone fractures, including the clivus. Although the CSF rhinorrhea was treated conservatively for a week, clinical symptoms did not improve and surgical repair was performed. Preope...

According to the classical hypothesis of the cerebrospinal fluid (CSF) hydrodynamics, CSF is produced inside the brain ventricles, than it circulates like a slow river toward the cortical subarachnoid space, and finally it is absorbed into the venous sinuses. Some pathological conditions, primarily hydrocephalus, have also been interpreted based on this hypothesis. The development of hydrocepha...

OBJECTIVE (1) To determine the concentration of Taenia antigens in the cerebrospinal fluid (CSF) of patients with neurocysticercosis (NC); (2) to establish its relationship with clinical activity of the disease and with classical variables of CSF. METHOD A CSF examination was performed in one sample from 36 patients with definitive diagnosis of NC, including: quantitative and cytomorphologica...

CEREBROSPINAL FLUID PRESSURE Evidence supports the association of low cerebrospinal fluid (CSF) pressure with the prevalence of glaucoma, particularly with respect to normal-tension glaucoma (NTG). The most robust study comes from Tongren Hospital in Beijing, China, in which patients with both high-tension and normal-tension open-angle glaucoma as well as healthy controls underwent lumbar punct...

The microhaemagglutination assay for Treponema pallidum antibodies (MHA:TP-CSF), the Veneral Disease Research Laboratory (VDRL-CSF), and the fluorescent treponemal antibody (FTA-CSF) tests were used to detect treponemal antibodies in 3157 samples of cerebrospinal fluid from patients with syphilis, with neurological, metabolic, or immunological disorders, and with undetermined diagnoses. An agre...

Cerebrospinal fluid (CSF) pressure and composition are generally thought to be homogeneous within small limits throughout all CSF compartments. CSF sampled during lumbar puncture therefore should be representative for all CSF compartments. On the basis of clinical findings, histology and biochemical markers, we present for the first time strong evidence that the subarachnoid spaces (SAS) of the...

b a c k ground: csf is a clear liquid that its mechanical properties are to a large extent similar to water properties. regarding the lack of a numerical index for diagnosis of diseases resulting from increased csf pressure such as hydrocephalus, evaluation of hydrodynamic conditions of csf in cerebral ventricular system is of great importance. methods: at first, the diagram of velocity in sylv...

many diseases are related to cerebrospinal .uid (csf) hydrodynamics. therefore, understanding the hydrodynamics of csf .ow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. furthermore, engineering a reliable computational method is promising approach for fabricating in vitro models which is essential for inventing gen...

A potential strategy to increase the efficacy of topotecan to treat central nervous system (CNS) malignancies is modulation of the activity of ATP-binding cassette (ABC) transporters at the blood-brain and blood-cerebrospinal fluid barriers to enhance topotecan CNS penetration. This study focused on topotecan penetration into the brain extracellular fluid (ECF) and ventricular cerebrospinal flu...