Magnesium (Mg) is essential for cell functions such as the transport of calcium and potassium ions, and modulates signal transduction, energy metabolism, and cell proliferation. Although mice have been used as models of various neurological diseases of humans, and for investigating the therapeutic effects of Mg, neither the normal concentration of Mg in cerebrospinal fluid (CSF), nor its respon...

High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebrospinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeability of the brain barriers can be studied by using...

The concentrations of inorganic ions and glucose in the plasma and CSF of 11 patients with "steady-state" chronic renal failure have been measured and their CSF: plasma interrelations studied. The results have been compared with the corresponding data from 34 control subjects. In the patients with renal failure, there was a positive correlation between raised CSF and plasma potassium concentrat...

The general anesthetic propofol has been in clinical use for more than 30 years and has become the agent of choice for rapid intravenous induction. While its hypnotic and anti-convulsant properties are well known, the propensity for propofol to promote seizure activity is less well characterised. Electroencephalogram-confirmed reports of propofol-induced seizure activity implicate a predisposit...

The author presents an unusual extension of the cerebrospinal fluid space into the proximal tympanic part of the facial nerve, and points out the clinical and surgical significance of this anatomical variation.

1. Plasma and erythrocyte magnesium concentrations have been determined in fifty-five patients on regular haemodialysis and in thirty-two healthy subjects. The dialysis fluid magnesium concentrations of the former were 0.58,0.9 and 1.73 m ~ . 2. There was a linear correlation between the plasma and erythrocyte magnesium concentrations of normal subjects and dialysed patients whose dialysis flui...