نتایج جستجو برای: cervical cancer cells
تعداد نتایج: 2144225 فیلتر نتایج به سال:
Cervical reserve cells are epithelial progenitor cells that are pathologically evident as the origin of cervical cancer. Thus, investigating the characteristics of cervical reserve cells could yield insight into the features of cervical cancer stem cells (CSCs). In this study, we established a method for the regeneration of cervical reserve cell-like properties from human induced pluripotent st...
PURPOSE Cervical cancer cells are addicted to the expression of the human papillomavirus (HPV) oncoproteins E6 and E7. The oncogencity of E6 is mediated in part by targeting p53 and PDZ-family tumor suppressor proteins for rapid proteasomal degradation, whereas the E7 oncoprotein acts in part by coopting histone deacetylases (HDAC)1/2. Here, we examine the hypothesis that inhibition of proteaso...
BACKGROUND Cervical cancer is the 2nd most frequently diagnosed gynecological cancer. Therefore, it clinically significant to discover an effective anti-cancer approach. OBJECTIVES This study aimed investigate effects of low-intensity ultrasound irradiation (USI) on cervical cells and associated mechanisms cell death. MATERIAL AND METHODS Normal human HaCaT lines C33A, Hela Siha were cultured γ...
MiR-181 was highly expressed in lung cancer cells of cisplatin-resistance. In this study, we sought to explore the connection of miR-181 expression with cell proliferation, invasion and apoptosis in cervical cancer cells. Real-time polymerase chain reaction and Western blot were performed to determine the expression level of miR181 at mRNA and protein level. Then MTT and flow cytometry were res...
Introduction: Cancer is the leading cause of death in most countries. There are several methods used to treat cancer. Doxorubicin is one of the most important chemotherapy drugs that has several side effects, such as infertility, hyperuricemia, neuropathy, and cardiomyopathy. This study aimed to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human c...
Cervical cancer is caused by infection with the human papilloma virus which can infect genitals, anus,throat, mouth and cells on surface of skin. often late so that it cause death,so efforts are needed to reduce risk factors for cervical cancer, namely through primary preventionefforts. The purpose this study was determine relationship between cervicalcancer prevention behavior in adolescent gi...
Background and Objective: Free radicals cause many diseases in human and their neutralizing by antioxidants reduces risk of cancers. Salvia Officinalis from Lamiaceae family is one of the valuable plants in traditional medicine. The present study aimed to evaluate the antioxidative and cytotoxic properties of ethanolic extract of the aerial parts of this plant on human prostate and cervical can...
The protein CD24 is a cell surface protein that appears to function as an adhesion molecule; its expression has been shown to correlate with prognosis in a variety of tumors. Herein, we investigated the possible role and mechanism of CD24 in cervical cancer. Our results showed that CD24 was overexpressed in cervical cancer tissues compared with that in the adjacent non‑cancerous tissues by qPCR...
Background: Human papilloma virus (HPV) is one of the most important factors in cervical cancer. Viral sequences are integrated into the host cell genome. In mild cases the virus causes skin damages, in severe cases it leads to cancer. Like many other cancers, telomerase gene expression was increased in cervical cancer. This enzyme is a reverse transcriptase that contains two common subunits: i...
In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. I...
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