The histopathology of 12 patients with adenoma of the ampulla of Vater was examined to trace the adenoma-carcinoma sequence of the ampulla of Vater. Immunohistochemistry for carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 was also performed. Four large adenomas with mild dysplasia also had foci of moderate dysplasia while another one contained foci of severe dysplasia (intramu...

BACKGROUND In organized screening programmes for cervical cancer, pre-cancerous lesions are detected by cervical smears. However, during follow-up after a positive smear these pre-cancerous lesions are not always found. The purpose of the study is to analyse positive diagnostic values of smears of at least mild dysplasia, made under the organized screening programmes in the Rotterdam area (1979...

Over the past 50 years, the incidence and mortality of cervical cancer has decreased by 75 percent in developed countries because of the availability of screening program for cervical precancer and human papilloma virus (HPV) vaccination. In developing countries, however, cervical cancer remains the second most common type of cancer and cause of cancer death in women. This is most likely due to...

conclusions our study shows that prevalence of hpv infection in cervical biopsy samples collected from suspected patients in khouzestan province is slightly higher than other provinces of iran. since hpv cervical infection, is an indicator for the host cervical cancer progression, parallel with pap smear test, pcr detection of hpv dna in biopsy of suspected cases is recommended. results out of ...

S ince the development and wide implementation of cervical cancer screening programs, cervical cancer rates have decreased by up to 80%.1 Screening has increased the identification of cervical intraepithelial neoplasia (CIN), carcinoma in situ (CIS), and cervical dysplasia in young women during their reproductive years. In fact, the International Federation of Gynecologists and Obstetricians (F...

Predicting disease outcome is a major challenge in modern medicine. Concerning the prediction of HPV-associated cervical disease, several important issues are related both to the management of women with diagnosed cervical precancer and cancer. The detailed molecular mechanisms explaining the different oncogenic potential of the LR-HPVand HR-HPV have emerged only recently. Oncogenic HPVs are ca...

BACKGROUND To evaluate the usefulness of this biomarker in the diagnosis of cases of cervical neoplasia we studied the immunohistochemical expression of p16INK4a in a large series of archival cervical biopsies arranged into tissue microarray format. METHODS TMAs were constructed with tissue cores from archival formalin fixed, paraffin-embedded donor tissues from 796 patients, and included cas...

OBJECTIVES To study the diagnostic potential of optical imaging and its comparison with colposcopy, in detecting early cervical dysplasia. METHODS The study was conducted on 200 patients attending the outdoor of UISE maternity hospital with symptoms suspicious of cervical lesions. All patients were subjected to colposcopy, followed by histo-pathological examination. Out of all HPE, 18 samples...