Humans have lived with chemical pollution for thousands of years, but the recent proliferation of industrial chemicals poses novel threats. In the new book Only One Chance, distinguished environmental health researcher Philippe Grandjean argues for special attention to developmental neurotoxicology, i.e. to the effects of chemical pollution on the developing human brain during pregnancy and in ...

objective: to compare the effectiveness of letrozole and clomiphene citrate (cc) on uterine blood flow rate in patients with unexplained infertility. materials and methods: in this randomized clinical trial 90 women with unexplained infertility referred to a university clinic from january 2011- december 2013 were enrolled. thirty patients were randomized for letrozole, 30 patients for cc and 3o...

Exposure to environmental chemicals with estrogenic activity during the early stage of pregnancy can seriously affect embryonic development and the maintenance of pregnancy. To estimate the metabolism and pharmacodynamics of a xenoestrogen, bisphenol A, in a reproductive organ, the metabolite of bisphenol A was analyzed after incubating a rat uterine sac in buffer solutions containing the chemi...

objective: to compare the pregnancy outcomes achieved by in vitro fertilization (ivf) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (pors). materials and methods: in this randomized controlled trial, 77 pors undergoing ivf were selected and divided into two groups. first group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphe...

Published findings from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study regarding the relation between environmental chemicals and couple fecundity, as measured by time-to-pregnancy (TTP), are reviewed with a particular focus on role of the male partner. The LIFE Study recruited 501 couples from 16 counties in two U.S. states upon discontinuing contraception for pur...