This paper describes the system developed by the UTH-CCB team from the University of Texas Health Science Center at Houston (UTHealth), for the 2015 BioCreative V shared tasks of Track 3 on extraction of chemical disease relation (CDR). We participated in both tasks: Task A for “Disease Named Entity Recognition and Normalization (DNER)” and Task B for “Chemical-induced Diseases Relation Extract...

We describe a pipeline system, Named Entity Recognizer of Chemicals (NEROC), that aims to identify chemical entities mentioned in free texts. The system is based on a machine learning approach, a Conditional Random Field (CRF), and a selection of feature sets that are used to capture specific characteristics of chemical named entities. In this paper, we report results that produced by CRF model...

To identify chemical entities and drug names in patent according to CHEMDNER patent task-CEMP subtask, we use machine learning technique to construct a chemical named entity recognition (CNER) system. It is desirable for machine-based CNER system to have large training examples. Two CHEMDNER corpora have been developed. One is the corpus for the patent task and the other is the CHEMDNER corpus ...

The ranking and prediction of novel therapeutic categories for existing drugs (drug repositioning) is a challenging computational problem involving the analysis of complex chemical and biological networks. In this context we propose a novel semi-supervised learning problem: ranking drugs in integrated bio-chemical networks according to specific DrugBank therapeutic categories. To deal with this...

Sixteen derivatives of 1-(beta-D-arabinofuranosyl)-2-thiocytosine (araSC), including five 5'-esters, three 3'-esters, five N4-amides and three 5'-phosphodiesters, were synthesized and their reactivity to mouse tissue homogenates, including plasma, liver and intestine, and antitumor activity in mice bearing P388 cells were measured. The ester derivatives had a potent effect on the enzyme systems...

BACKGROUND The aim of this study was to investigate the association between the two most commonly used generic and disease specific health-related quality of life (HRQoL) measures in patients with chronic lung disease due to SM: Medical Outcomes Study Short Form 36-Item (SF-36) and St George's Respiratory Questionnaire (SGRQ). METHODS This is a secondary analysis of Iranian Chemical Warfare V...

Integral cross sections and thermal rate constants have been calculated for the N((2)D)+H(2) reaction and its isotopic variants N((2)D)+D(2) and the two-channel N((2)D)+HD by means of quasiclassical trajectory and statistical quantum-mechanical model methods on the latest ab initio potential-energy surface [T.-S. Ho et al., J. Chem. Phys. 119, 3063 (2003)]. The effect of rotational excitation o...