Introduction: All over the world autoimmune diseases and one of the classic examples of such diseases myasthenia gravis are on the rise. This progressing autoimmune disease characterized by pathological muscle weakness and increased fatigue. The literature describes the cause of myasthenia as production of autoantibodies to acetylcholine receptor subunits thereof. However myasthenia inherent im...

BACKGROUND Myasthenia gravis is characterized by weakness and fatigability of different muscle groups, including ocular, bulbar and the limbs. Therefore, a measure of disease severity at the impairment level in myasthenia needs to reflect all the relevant impairments, as well as their variations with activity and fatigue. We conducted a qualitative study of patients with myasthenia, to explore ...

Grave’s disease is the most common cause of hyperthyroidism in children. Symptoms of hyperthyroidism associated with Grave’s disease include goiter, tachycardia, tremor or diplopia caused by exophthalmos. Marked fatigue and weight loss may be observed due to hypermetabolic state. Myasthenia Gravis is far less frequent, with juvenile onset in fewer than 10% of the patients. Ocular symptoms: ptos...

Myasthenia gravis is an autoimmune disorder affecting the neuromuscular junction. Ocular myasthenia gravis presents as ptosis with extraocular motility restriction and is prone to be misdiagnosed as third nerve palsy or congenital or aponeurotic ptosis. Juvenile ocular myasthenia gravis in very young children is difficult to diagnose and can be easily labeled as a case of congenital ptosis, the...

BACKGROUND In the investigation of patients with myasthenia gravis, repetitive supramaximal stimulation of an affected peripheral nerve is commonly performed to detect abnormal transmission at the neuromuscular junction. A study was undertaken to determine whether abnormal transmission could similarly be detected during stimulation of the phrenic nerves. METHODS The phrenic nerves were stimul...

Before describing the two following cases of myasthenia gravis, which is also called myasthenia pseudo-paralytica, or asthenic bulbar paralysis, it may be well to recapitulate the chief features

Myasthenia Gravis (MG) is an autoimmune disorder characterized clinically by fluctuating muscle weakness and fatigability on exertion. The disease is caused by specific autoantibodies against proteins of the neuromuscular junction (NMJ) (Conti-Fine et al, 2002; Sanders & Meriggioli, 2009). Two different autoantibodies are routinely detectable, i.e. antibodies against the acetylcholine receptor ...

Myasthenia gravis is an archetypal human autoimmune disease. Thymectomy proven effective by controlled clinical trials, and commonly part of the immunotherapeutic approach when myasthenia creates generalized weakness. Pemphigus foliaceus also but treated medically; thymectomy not therapy unless thymoma discovered. Autoimmune mechanisms, age distribution, response to in disorders are likely be d...