Acute lung injury is a principal cause of morbidity and mortality in response to mustard gas (SM) inhalation. Obstructive, fibrin-containing airway casts have recently been reported in a rat inhalation model employing the SM analog 2-chloroethyl ethyl sulfide (CEES). The present study was designed to identify the mechanism(s) causing activation of the coagulation cascade after CEES-induced airw...

the zinc-cadmium oxide (zno-cdo) nanocomposites with different weight percentages of cadmium oxide (cdo) nanoparticles were successfully synthesized by the sonochemical method using zinc and cadmium nitrates as precursors to probe their nano-structured surfaces for the decomposition reactions of chloroethyl phenyl sulfide (ceps) as a surrogate of sulfur mustard agent simulant. scanning electron...

n,n-dichloropolystyrene sulfonamide as a decontaminant was synthesized in 5 steps from styrene monomer. styrene was first polymerized. then, sulfonation reaction was performed by h2so4 (c) followed by chlorination with pocl3 obtain chlorosulfonated polystyrene. amidification reaction was then applied to get sulfonamide resin. sulfonamide resin was treated with sodium hypochloride to obtain n,n-...

Sulfur mustard (SM), a chemical warfare agent, is strong alkylating compound that readily reacts with numerous biomolecules. The goal of the present work was to define and validate new biomarkers exposure SM could be easily accessible in urine or plasma. Because investigations using are prohibited by Organization for Prohibition Chemical Weapons, we worked 2-chloroethyl ethyl sulfide (CEES), mo...

The induction of sister chromatid exchanges (SCE) and mutation at the hypoxanthine-guanine phosphoribosyl transferase locus and toxicities of 40 different chemical and physical agents were examined on Chinese hamster V79 cells. These agents included mono-, di-, tri-, and polyfunctional alkylating agents, intercalators, gamma-rays, and UV light irradiation. Mutation was measured as resistance to...

Although the antitumor effects of chloroethylnitrosoureas have been shown to be due primarily to DNA-DNA cross-linking by the alkylating moieties of these agents, the basis of the often accompanying bone marrow toxicity has been more controver sial. We report on the relative bone marrow toxicity of four model nitrosoureas with different alkylating and Carbamoylating activi ties: 1,3-bis(2-chlor...